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<!--Generated by Squarespace Site Server v5.11.81 (http://www.squarespace.com/) on Tue, 29 May 2012 08:32:04 GMT--><feed xmlns="http://www.w3.org/2005/Atom" xmlns:dc="http://purl.org/dc/elements/1.1/"><title>Start a Dispensary | Marijuana Information Blog</title><subtitle>Start a Dispensary | Marijuana Information Blog</subtitle><id>http://www.lcitraining.com/journal/</id><link rel="alternate" type="application/xhtml+xml" href="http://www.lcitraining.com/journal/"/><link rel="self" type="application/atom+xml" href="http://www.lcitraining.com/journal/atom.xml"/><updated>2012-02-28T03:47:33Z</updated><generator uri="http://www.squarespace.com/" version="Squarespace Site Server v5.11.81 (http://www.squarespace.com/)">Squarespace</generator><entry><title>7 Cannabis Studies That Will Change Everything</title><category term="cannabis"/><category term="education"/><category term="marijuana"/><category term="nicole scott"/><category term="ron marczyk"/><category term="science"/><category term="steve elliot"/><category term="tokeofthetown"/><category term="training"/><id>http://www.lcitraining.com/journal/2012/2/27/7-cannabis-studies-that-will-change-everything.html</id><link rel="alternate" type="text/html" href="http://www.lcitraining.com/journal/2012/2/27/7-cannabis-studies-that-will-change-everything.html"/><author><name>Legal Cannabis Institute</name></author><published>2012-02-28T02:28:43Z</published><updated>2012-02-28T02:28:43Z</updated><content type="html" xml:lang="en-US"><![CDATA[<p>By Steve Elliott<br />tokeofthetown.com</p>
<p><strong><span>Worth Repeating<br /><em><strong><span class="mt-enclosure-image mt-enclosure">​</span>By Ron Marczyk, R.N.</strong></em>&nbsp;</span></strong></p>
<p>Since the 1960s, the major milestones our country has achieved&nbsp;are incredible.</p>
<p>We elected an African-American president, women&#8217;s issues have&nbsp;made tremendous progress, and gays and lesbians can marry.</p>
<p>But cannabis is still illegal&#8230;? <em>Not for long!</em></p>
<p>As the tsunami of hard empirical positive medical cannabis&nbsp;research builds, it meets the inevitable changing younger&nbsp;demographics of our country, and with the need for new&nbsp;cannabis- based jobs and new tax revenue.</p>
<p>The cannabis legalization tipping point is close at hand!</p>
<p>&#8220;Cannabis is the people&#8217;s medicine&#8221; and has overwhelming public support.</p>
<p>Let&#8217;s knock this last domino over!</p>
<p>And to that end&#8230;</p>
<p>I would like to highlight several 2011 research papers that discuss the most current findings regarding medical&nbsp;cannabis treatment and disease prevention.</p>
<p>The following medical papers focus on:</p>
<p style="padding-left: 30px;">&bull; Cancer and colon cancer prevention,</p>
<p style="padding-left: 30px;">&bull; Inflammatory bowel disease, irritable bowel syndrome, colitis, Crohn&#8217;s disease</p>
<p style="padding-left: 30px;">&bull; Vomiting from chemotherapy</p>
<p style="padding-left: 30px;">&bull; Osteoporosis</p>
<p style="padding-left: 30px;">&bull; Traumatic brain injury</p>
<p style="padding-left: 30px;">&bull; Heart disease /Heart attack</p>
<p>The concept of the endocannabinoid system was outlined a mere 14 years ago, and look how far we have&nbsp;come!</p>
<p>Today &#8220;<span>phytocannabinoid therapeutics</span>&#8221; is the newest, fastest growing field in medical research.</p>
<p>As this medical cannabis evidence-based tsunami approaches, its main therapeutic action appears&nbsp;<span>to </span>restoring homeostasis to multiple body systems<span>.</span></p>
<p>The <span>action by which phytocannabinoids heal </span>is by reestablishing the proper immune set points within CB 1/2&nbsp;receptors in both brain and body.</p>
<p><span>Research supports medical cannabis </span><em>as important a medical discovery as insulin or penicillin were in their&nbsp;</em><em>day</em><span>.</span></p>
<p>Perhaps the root of many human illnesses is an <span>anandamide deficiency</span>, which, when corrected and&nbsp;rebalanced by THC intake, produces <span>homeostasis</span>.</p>
<p>Whatever <span>anandamide </span>does in the body, phytocannabinoids mimic. My prediction is that phytocannabinoids&nbsp;will ultimately be found to be an vital to human health.</p>
<p><em>Phytocannabinoids mimic the same actions of Anandamide in the brain and body, which maintain&nbsp;</em><em>homeostasis, maintaining wellness and disease prevention!</em></p>
<p><em><span class="full-image-block ssNonEditable"><span><img style="width: 600px;" src="http://www.lcitraining.com/storage/Cannabinoid%20Uses.jpg?__SQUARESPACE_CACHEVERSION=1330397381402" alt="" /></span><span class="thumbnail-caption" style="width: 600px;">Graphic: TRENDS In Pharmacological Sciences Pharmacological actions of non-psychotropic cannabinoids (with the indication of the proposed mechanisms of action). Abbreviations: D 9 -THC, D 9 -tetrahydrocannabinol; D 8 -THC, D 8 -tetrahydrocannabinol; CBN, cannabinol; CBD, cannabidiol; D 9 -THCV, D 9 -tetrahydrocannabivarin; CBC, cannabichromene; CBG, cannabigerol; D 9 -THCA, D 9 -tetrahydrocannabinolic acid; CBDA, cannabidiolic acid; TRPV1, transient receptor potential vanilloid type 1; PPARg, peroxisome proliferator-activated receptor g; ROS, reactive oxygen species; 5-HT1A, 5-hydroxytryptamine receptor subtype 1A; FAAH, fatty acid amide hydrolase. (+), direct or indirect activation; &#8220;, increase; #, decrease. </span></span></em></p>
<p><strong>It&#8217;s All About THC</strong></p>
<p>THC is unique, in that it is only found in one plant on earth.</p>
<p>The female cannabis plant is a THC-resin factory.&nbsp;THC, which makes up the plant&#8217;s resin, has the&nbsp;important job of collecting pollen from the male&nbsp;plant for fertilization. No THC-laced resin, no&nbsp;seed production. Additionally, this resin tastes&nbsp;very bad to herbivores, which leave it alone, and&nbsp;it also offers superior UV protection to the plant at&nbsp;high altitudes.</p>
<p>A cannabis sativa flower coated with trichomes,&nbsp;which contain more THC than any other part of&nbsp;the plant&nbsp;The cannabis plant has only two functions: to&nbsp;make THC and seeds.</p>
<p>THC is the most abundant &#8220;<span>phytocannabinoid</span>&#8220;&nbsp;within the cannabis plant.&nbsp;All other THC-like substances in the plant are&nbsp;THC intermediate metabolites being assembled by&nbsp;the plant on their way to becoming THC.&nbsp;Once the plant is cut down and dies, the THC degrades into cannabindiol. Cannabinol (CBN) is the primary&nbsp;product of THC degradation, and there is usually little of it in a fresh plant. CBN content increases as THC&nbsp;degrades in storage, and with exposure to light and air, and it is only mildly psychoactive.</p>
<p>Why would just this one plant, and the phytocannabinoids it produces control not one, but two dedicated&nbsp;molecular receptors for phytocannabinoids, with more predicted to still be discovered?&nbsp;Did evolution intend for them to be naturally consumed for proper body function? As any other plant-derived&nbsp;antioxidant?</p>
<p><strong>How THC talks to the brain and immune system</strong></p>
<p>All healing, cancer fighting and aging in your&nbsp;body is controlled by the immune system.<span class="full-image-float-right ssNonEditable"><span><img src="http://www.lcitraining.com/storage/marijuana-brain-thumb-370x349.gif?__SQUARESPACE_CACHEVERSION=1330397806884" alt="" /></span><span class="thumbnail-caption" style="width: 370px;">Graphic: How Stuff Works</span></span></p>
<p><span>Phytocannabinoids </span>appear to control the&nbsp;activity level of the immune system up or&nbsp;down, so that it doesn&#8217;t attack its host or&nbsp;respond too weakly to cellular dysfunction.&nbsp;Whenever you hear the term &#8220;antiinflammatory&nbsp;activity,&#8221; think &#8220;cannabis&nbsp;immune system control.&#8221;</p>
<p>CB1 cannabigenic receptors are the majority&nbsp;of receptor type in the synaptic clef. THC activated&nbsp;CB1 brain receptors directly link up&nbsp;and control the microglial cells in the brain;&nbsp;the microglia is the specialized white blood&nbsp;cells that make up the brain&#8217;s dedicated&nbsp;immune system.</p>
<p><span>Cannabidiol </span>is degraded THC. It activates CB2 receptors mostly in the body. In both cases, THC controls&nbsp;both immune systems (brain and body), in one form or another. It seems that CB1 brain receptors link up to&nbsp;CB2 body receptors, which in turn control many autoimmune diseases.</p>
<p>The word used to describe this cannabis brain/body link up is <span>Psychoneuroimmunology</span>.</p>
<p>Mind = neurotransmitter = immune system communication system, or in this case&nbsp;&#8221;<span>Cannabinergic </span>Psychoneuroimmunology&#8221; &#8212; cannabinoid-induced immune system healing.</p>
<p>Cannabis consciousness repairs your immune system: never underestimate the power of a bong hit!</p>
<p><strong>#1: &#8220;The Endocannabinoid System and Cancer: Therapeutic Implication&#8221;</strong></p>
<p><strong><em>The British Journal of Pharmacology, 2011</em></strong></p>
<p>Findings: Delta 9 THC as a treatment for breast, prostate, brain and bone&nbsp;cancer</p>
<p>&#8220;This review updates the relationship between the endocannabinoid&nbsp;system and anti-tumor actions (inhibition of cell proliferation and migration,&nbsp;induction of apoptosis, reduction of tumor growth) of the cannabinoids in&nbsp;different types of cancer.&#8221;</p>
<p>&#8220;The therapeutic potential of cannabinoids for cancer, as identified in&nbsp;clinical trials, is also discussed. Identification of safe and effective&nbsp;treatments to manage and improve cancer therapy is critical to improve&nbsp;quality of life and reduce unnecessary suffering in cancer patients.&#8221;</p>
<p>&#8220;In this regard, cannabis-like, compounds offer therapeutic potential for the treatment of breast, prostate and&nbsp;bone cancer in patients. Further basic research on anti-cancer properties of cannabinoids as well as clinical&nbsp;trials of cannabinoid therapeutic efficacy in breast, prostate and bone cancer is therefore warranted.&#8221;</p>
<p>&#8220;The available literature suggests that the endocannabinoid system may be targeted to suppress the&nbsp;evolution and progression of breast, prostate and bone cancer as well as the accompanying pain syndromes.&nbsp;Although this review focuses on these three types of cancer, activation of the endocannabinoid signaling&nbsp;system produces anti-cancer effects in other types of cancer including skin, brain gliomas and lung.&#8221;</p>
<p>&#8220;Interestingly, cannabis trials in population based studies failed to show any evidence for increased risk of&nbsp;respiratory symptoms/chronic obstructive pulmonary disease or lung cancer (Tashkin, 2005) associated with&nbsp;smoking cannabis.&#8221;</p>
<p>&#8220;Moreover, synthetic cannabinoids (Delta 9 THC) and the endocannabinoid system play a role in inhibiting&nbsp;cancer cell proliferation and angiogenesis, reducing tumor growth and metastases and inducing apoptosis (self destruction for cancer cells) in all three types of cancers reviewed here.</p>
<p>&#8220;These observations raise the possibility that a dysregulation of the endocannabinoid system may promote&nbsp;cancer, by fostering physiological conditions that allow cancer cells to proliferate, migrate and grow.&#8221;</p>
<p>IMPORTANT: This is a very intriguing observation. What is being implied here is that some people may be&nbsp;suffering from an anandamide deficiency! Just as a diabetic is insulin deficiencient and must supplement their&nbsp;body with insulin, in this case THC is the vital medicine needed to replace low levels of anandamide.</p>
<p>These observations also raise the exciting possibility that enhancing cannabinoid tone (code for THC locking&nbsp;into the CB1 receptor) through cannabinoid based pharmacotherapies may attenuate these harmful&nbsp;processes to produce anti-cancer effects in humans.</p>
<p>Bottom line: Smoking marijuana prevents cancer body-wide.</p>
<p><strong>#2: &#8220;Update on the Endocannabinoid System as an Anticancer Target&#8221;</strong></p>
<p>Expert Opinion on <em>Therapeutic Targets</em>, March 2011<span class="full-image-float-right ssNonEditable"><span><a href="http://www.safeaccessnow.org/" target="_blank"><img src="http://www.lcitraining.com/storage/icon_closerlook.jpeg?__SQUARESPACE_CACHEVERSION=1330399108656" alt="" /></a></span><span class="thumbnail-caption" style="width: 216px;">Americans for Safe Access</span></span></p>
<p>Findings: antitumor effects, cancer prevention</p>
<p>&#8220;Recent studies have shown that the endocannabinoid system (ECS)&nbsp;could offer an attractive antitumor target. Numerous findings suggest&nbsp;the involvement of this system (constituted mainly by cannabinoid&nbsp;receptors, endogenous compounds and the enzymes for their synthesis and degradation) in cancer cell&nbsp;growth in vitro and in vivo.&#8221;</p>
<p>&#8220;This review covers literature from the past decade which highlights the potential of targeting the ECS for&nbsp;cancer treatment. In particular, the levels of endocannabinoids and the expression of their receptors in&nbsp;several types of cancer are discussed, along with the signaling pathways involved in the endocannabinoid&nbsp;antitumor effects.&#8221;</p>
<p>&#8220;Furthermore, targeting the ECS with agents that activate cannabinoid receptors (This means THC) or&nbsp;inhibitors of endogenous degrading systems such as fatty acid amide hydrolase inhibitors may have relevant&nbsp;therapeutic impact on tumor growth. Additional studies into the downstream consequences of&nbsp;endocannabinoid treatment are required and may illuminate other potential therapeutic targets.&#8221;</p>
<p><strong>#3: &#8220;Cannabinoids and the gut: new developments and emerging concepts&#8221;</strong></p>
<p><em>Pharmacology &amp; Therapeutics, April, 2010</em></p>
<p>Findings: THC and inflammatory bowel disease, irritable bowel&nbsp;syndrome (IBS), colitis, colon cancer, vomiting/chemotherapy</p>
<p>&#8220;Disorders of the gastrointestinal (GI) tract have been treated with&nbsp;herbal and plant-based remedies for centuries. Prominent amongst&nbsp;these therapeutics are preparations derived from the marijuana&nbsp;plant Cannabis. Cannabis has been used to treat a variety of GI&nbsp;conditions that range from enteric infections and inflammatory&nbsp;conditions, including inflammatory bowel disease (IBD) to disorders&nbsp;of motility, emesis and abdominal pain.&#8221;<span class="full-image-float-left ssNonEditable"><span><img src="http://www.lcitraining.com/storage/Screen%20Shot%202011-08-07%20at%201.08.42%20PM-thumb-336x279.png?__SQUARESPACE_CACHEVERSION=1330399461963" alt="" /></span><span class="thumbnail-caption" style="width: 336px;">Sites of action of cannabinoids in the enteric nervous system. CB2 receptors indicated with the marijuana leaf.</span></span></p>
<p>&#8220;Cannabis has been used to treat gastrointestinal (GI) conditions that range from enteric infections and&nbsp;inflammatory conditions to disorders of motility, emesis and abdominal pain.&#8221;</p>
<p>&#8220;The mechanistic basis of these treatments emerged after the discovery of Delta(9)-tetrahydrocannabinol as&nbsp;the major constituent of Cannabis. Further progress was made when the receptors for Delta(9)-&nbsp;tetrahydrocannabinol were identified as part of an endocannabinoid system, that consists of specific&nbsp;cannabinoid receptors.&#8221;</p>
<p>&#8220;Anatomical, physiological and pharmacological&nbsp;studies have shown that the endocannabinoid&nbsp;system is widely distributed throughout the gut,&nbsp;with regional variation and organ-specific actions.&#8221;&nbsp;(CB2 receptors are embedded within the lining of&nbsp;the intestines in large numbers.)</p>
<p>&#8220;They are involved in the regulation of food intake,&nbsp;nausea and emesis, gastric secretion and gastro&nbsp;protection, GI motility, ion transport, visceral&nbsp;sensation, intestinal inflammation and cell&nbsp;proliferation in the gut.&#8221;</p>
<p>&#8220;As we have shown, the endocannabinoid system&nbsp;is widely distributed throughout the gut, with&nbsp;regional variation and specific regional or organ-specific actions.&#8221;</p>
<p>&#8220;CB2 receptors are involved in the regulation of food intake, nausea and emesis, gastric secretion and gastro&nbsp;protection, GI motility, ion transport, visceral sensation, intestinal inflammation and cell proliferation (cancer)&#8221;</p>
<p>&#8220;Preclinical models have shown that modifying the&nbsp;endocannabinoid system can have beneficial effects&#8230;.&nbsp;Pharmacological agents that act on these targets have been&nbsp;shown in preclinical models to have therapeutic potential.&#8221; [THC&nbsp;is the Pharmacological agent mentioned.]</p>
<p><strong>Colorectal Cancer Prevention Model<span class="full-image-float-right ssNonEditable"><span><img src="http://www.lcitraining.com/storage/Screen Shot 2011-08-07 at 1.10.04 PM-thumb-258x209.png?__SQUARESPACE_CACHEVERSION=1330399510708" alt="" /></span><span class="thumbnail-caption" style="width: 258px;">How THC/cannabidiol activates the CB1/2 receptors to shut down colon cancer by signaling cancer cells to self-destruct</span></span><br /></strong></p>
<p>Cannabiols via CB1 and possibly CB2 receptor activation, have&nbsp;been shown to exert apoptotic actions in several colorectal&nbsp;cancer cell lines.</p>
<p>See the illustration at left for how THC/cannabidiol activates the&nbsp;CB1/2 receptors to shut down colon cancer by signaling cancer cells to self-destruct.</p>
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<p><strong>#4: &#8220;Gut feelings about the endocannabinoid system&#8221;</strong></p>
<p><em>Journal of Gastrointestinal Motility, </em>May 2011</p>
<p>Findings: Stemming from the centuries old&nbsp;and well known effects of Cannabis&nbsp;on intestinal motility and secretion,&nbsp;research on the role of the&nbsp;endocannabinoid system in gut function&nbsp;and dysfunction has received ever&nbsp;increasing attention since the discovery&nbsp;of the cannabinoid receptors and their&nbsp;endogenous ligands, the&nbsp;endocannabinoids.</p>
<p><span class="full-image-float-left ssNonEditable"><span><img src="http://www.lcitraining.com/storage/v1i3a7_001lg-thumb-400x300.jpeg?__SQUARESPACE_CACHEVERSION=1330399913809" alt="" /></span><span class="thumbnail-caption" style="width: 400px;">Graphic: CMR Journal Schematic illustration of the functional roles of the endocannabinoid system (ECS) in the gastrointestinal tract. The ECS regulates four major functional elements in the gut: motility, secretion, inflammation, and sensation in health and disease. Major components of the ECS that have been defined in each of these functional roles are shown: CB1 and CB2 receptors, anandamide (AEA), fatty acid amide hydrolase (FAAH), and the endocannabinoid membrane transporter (EMT). For motility, the CB2 receptors only appear to be active under pathophysiological conditions and are shown italicized.</span></span>In this article, some of the most recent&nbsp;developments in this field are&nbsp;discussed, with particular emphasis on&nbsp;new data, most of which are published&nbsp;in <em>Neurogastroenterology &amp; Motility</em>, on&nbsp;the potential tonic endocannabinoid&nbsp;control of intestinal motility, the function&nbsp;of cannabinoid type-1 (CB1) receptors&nbsp;in gastric function, visceral pain,&nbsp;inflammation and sepsis, the emerging role of cannabinoid type-2 (CB2) receptors in the gut, and the&nbsp;pharmacology of endocannabinoid-related molecules and plant cannabinoids not necessarily acting via&nbsp;cannabinoid CB1 and CB2 receptors.</p>
<p>These novel data highlight the multi-faceted aspects of endocannabinoid function in the GI tract, support the&nbsp;feasibility of the future therapeutic exploitation of this signaling system for the treatment of GI disorders, and&nbsp;leave space for some intriguing new hypotheses on the role of endocannabinoids in the gut.</p>
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<p><strong>#5: &#8220;Cannabinoids and the skeleton: from marijuana to reversal of bone loss&#8221;</strong></p>
<p><em>Annuals of Medicine</em><span>, 2009</span></p>
<p>Findings: CB2 receptors maintain bone remodeling balance, thus&nbsp;protecting the skeleton against age-related bone loss.</p>
<p>The active component of marijuana, Delta(9)-&nbsp;tetrahydrocannabinol, activates the CB1 and CB2 cannabinoid&nbsp;receptors, thus mimicking the action of endogenous cannabinoids.</p>
<p>CB1 is predominantly neuronal and mediates the cannabinoid&nbsp;psychotropic effects. CB2 is predominantly expressed in peripheral tissues, mainly in pathological conditions.&nbsp;So far the main endocannabinoids, anandamide and 2-arachidonoylglycerol, have been found in bone at&nbsp;&#8216;brain&#8217; levels.</p>
<p>The CB1 receptor is present mainly in skeletal sympathetic nerve terminals, thus regulating the adrenergic&nbsp;tonic restrain of bone formation. CB2 is expressed in osteoblasts and osteoclasts, stimulates bone formation,&nbsp;and inhibits bone resorption.</p>
<p>Because low bone mass is the only spontaneous phenotype so far reported in CB2 mutant mice, it appears&nbsp;that the main physiologic involvement of CB2 is associated with maintaining bone remodeling at balance,&nbsp;thus protecting the skeleton against age-related bone loss.</p>
<p>Indeed, in humans, polymorphisms in CNR2, the gene encoding CB2, are strongly associated with&nbsp;postmenopausal osteoporosis. Preclinical studies have shown that a synthetic CB2-specific agonist rescues&nbsp;ovariectomy-induced bone loss.</p>
<p>Taken together, the reports on cannabinoid receptors in mice and humans pave the way for the development&nbsp;of 1) diagnostic measures to identify osteoporosis-susceptible polymorphisms in CNR2, and 2) cannabinoid&nbsp;drugs to combat osteoporosis.</p>
<p><span><strong>#6: &#8220;</strong></span><strong>Endocannabinoids and traumatic brain injury</strong><span><strong>&#8221;</strong></span></p>
<p>Findings: Traumatic brain injury (TBI) represents the leading&nbsp;cause of death in young individuals.</p>
<p>FINDING: THC activation of the CB1 receptor is the same&nbsp;as the action of anaidemide on CB1 This article discusses&nbsp;how anandamide increases in the brain after injury, so THC&nbsp;may have the potential to become a front line emergency&nbsp;medicine in the future.<span class="full-image-float-right ssNonEditable"><span><img src="http://www.lcitraining.com/storage/Endocannabinoid cell-thumb-281x190.jpg?__SQUARESPACE_CACHEVERSION=1330400268740" alt="" /></span><span class="thumbnail-caption" style="width: 281px;">Graphic: Fit Body Bootcamp</span></span></p>
<p>&#8220;There is a large body of evidence showing that eCB are&nbsp;markedly increased in response to pathogenic traumatic&nbsp;head injury events.&#8221;</p>
<p>&#8220;This fact, as well as numerous studies on experimental models of brain toxicity, neuroinflammation and&nbsp;trauma supports the notion that the eCB are part of the brain&#8217;s compensatory or repair mechanisms.&#8221;</p>
<p>These are mediated via CB receptors signalling pathways that are linked to neuronal survival and repair. The&nbsp;levels of 2-AG, the most highly abundant eCB, are significantly elevated after TBI and when administered to&nbsp;TBI mice, 2-AG decreases brain edema, inflammation and infarct volume and improves clinical recovery.( So&nbsp;would THC.)</p>
<p>This review is focused on the role the eCB system plays as a self-neuroprotective mechanism and its&nbsp;potential as a basis for the development of novel therapeutic modality for the treatment of CNS pathologies&nbsp;with special emphasis on TBI.</p>
<p>Bottom line: For proof see <span>U.S government 2003 patent</span></p>
<p><strong>#7: &#8220;Acute administration of cannabidiol in vivo suppresses ischaemia-induced cardiac arrhythmias</strong></p>
<p><strong>and reduces infarct size when given at reperfusion&#8221;</strong></p>
<p><em>British Journal of Pharmacology, </em>Aug. 2011</p>
<p>Findings: Cannabidiol (CBD) is a phytocannabinoid, with antiapoptotic,&nbsp;(the process of programmed cell death) anti-inflammatory&nbsp;and antioxidant effects and has recently been shown to exert a&nbsp;tissue sparing effect during chronic myocardial ischaemia and&nbsp;reperfusion (I/R).</p>
<p>However, it is not known whether CBD is cardioprotective in the&nbsp;acute phase of I/R injury and the present studies tested this&nbsp;hypothesis.</p>
<p>EXPERIMENTAL APPROACH: Male Sprague-Dawley rats received&nbsp;either vehicle or CBD (10 or 50 microg kg(-1) i.v.) 10 min before 30&nbsp;min coronary artery occlusion or CBD (50 microg kg(-1) i.v.) 10 min before reperfusion (2 h). The appearance&nbsp;of ventricular arrhythmias during the ischaemic and immediate post-reperfusion periods were recorded and&nbsp;the hearts excised for infarct size determination and assessment of mast cell degranulation. Arterial blood&nbsp;was withdrawn at the end of the reperfusion period to assess platelet aggregation in response to collagen.</p>
<p>KEY RESULTS: &#8220;CBD reduced both the total number of ischaemia-induced arrhythmias and infarct size when&nbsp;administered prior to ischaemia, an effect that was dose-dependent. Infarct size was also reduced when CBD&nbsp;was given prior to reperfusion. CBD (50 microg kg(-1) i.v.) given prior to ischaemia, but not at reperfusion,&nbsp;attenuated collagen-induced platelet aggregation compared with control, but had no effect on ischaemia induced&nbsp;mast cell degranulation.&#8221;</p>
<p>CONCLUSIONS AND IMPLICATIONS: &#8220;This study demonstrates that CBD is cardioprotective in the acute&nbsp;phase of I/R by both reducing ventricular arrhythmias and attenuating infarct size. The anti-arrhythmic effect,&nbsp;but not the tissue sparing effect, may be mediated through an inhibitory effect on platelet activation.&#8221;</p>
<p>Remember to exercise your ganja rights! Every day is a Ganja day!</p>
<p><em><span class="full-image-float-left ssNonEditable"><span><img src="http://www.lcitraining.com/storage/2011-04-14_14-18-03_72-thumb-250x235-1.jpeg?__SQUARESPACE_CACHEVERSION=1330400578396" alt="" /></span><span class="thumbnail-caption" style="width: 250px;">Photo: Ron Marczyk Mr. Worth Repeating: former NYPD cop, former high school health teacher, the unstoppable Ron Marczyk, R.N., Toke of the Town columnist</span></span>Editor&#8217;s note: Ron Marczyk is a retired high school health&nbsp;</em><em>education teacher who taught Wellness and Disease Prevention,&nbsp;</em><em>Drug and Sex Ed, and AIDS education to teens aged 13-17. He&nbsp;</em><em>also taught a high school International Baccalaureate psychology&nbsp;</em><em>course. He taught in a New York City public school as a Drug&nbsp;</em><em>Prevention Specialist. He is a Registered Nurse with six years of&nbsp;</em><em>ER/Critical Care experience in NYC hospitals, earned an M.S. in&nbsp;</em><em>cardiac rehabilitation and exercise physiology, and worked as a&nbsp;</em><em>New York City police officer for two years. Currently he is&nbsp;</em><em>focused on how evolutionary psychology explains human&nbsp;</em><em>behavior.</em></p>
]]></content></entry><entry><title>Judge sides with SD on medical marijuana- San Diego can refuse to issue business tax certificate</title><category term="DEA RAIDS"/><category term="adela falk"/><category term="business license"/><category term="law"/><category term="lcitraining"/><category term="legal cannabis institute"/><category term="marijuana"/><category term="nicole scott"/><category term="storefront"/><category term="wisdom organics"/><id>http://www.lcitraining.com/journal/2012/2/8/judge-sides-with-sd-on-medical-marijuana-san-diego-can-refus.html</id><link rel="alternate" type="text/html" href="http://www.lcitraining.com/journal/2012/2/8/judge-sides-with-sd-on-medical-marijuana-san-diego-can-refus.html"/><author><name>Legal Cannabis Institute</name></author><published>2012-02-08T17:08:21Z</published><updated>2012-02-08T17:08:21Z</updated><content type="html" xml:lang="en-US"><![CDATA[<h6>Written by&nbsp;<strong><a href="http://www.utsandiego.com/staff/christopher-cadelago/">Christopher Cadelago</a></strong></h6>
<p><span class="dateline">SAN DIEGO</span>&nbsp;&mdash; The city of San Diego can refuse to issue a certain type of business license to medical marijuana distributors, a judge has ruled.</p>
<p>Superior Court Judge Randa Trapp ruled the city cannot be required to take actions that amount to an illegal act.</p>
<p>Wisdom Organics of Lemon Grove is allowed to deliver medical marijuana under state law, but use and distribution of the drug remains illegal under federal law, Trapp wrote in the ruling Feb. 3.</p>
<p>&ldquo;Further, there is evidence presented that the U.S. Attorney is now putting marijuana dispensaries on notice that they are violating federal law and that federal law takes precedence over state law,&rdquo; Trapp wrote. &ldquo;Consequently, issuing a business tax certificate under these circumstances would tend to aid in an unlawful purpose.&rdquo;</p>
<p>A lawyer for the nonprofit organization did not return a message left at his office. It&rsquo;s unclear what affect the ruling will have on delivery services because unlike storefront dispensaries they operate largely under the radar of municipalities.</p>
<p>In April, Wisdom Organics sued the city after its treasurer refused to accept the nonprofit&rsquo;s application for a business tax certificate. According to court records, the collective grows medical marijuana outside of San Diego and applied for the license to operate as a delivery service in the city.</p>
<p>City Attorney Jan Goldsmith has brought dozens of lawsuits against medical marijuana dispensaries over the last year, arguing that they violate local zoning laws because the storefront operators are not allowed to operate anywhere in the city. That coupled with federal action has prompted the closure of scores of dispensaries &mdash; including U.S. Drug Enforcement Administration raids at dispensaries in Rolando, North Park, Pacific Beach, Kearny Mesa and elsewhere.</p>
<p>&ldquo;Marijuana distribution is a crime under federal law,&rdquo; Goldsmith said Tuesday. &ldquo;The city of San Diego will not enable a federal crime. Those who want to decriminalize marijuana for medicinal purposes should speak with members of Congress about changing federal law but, in the meantime, they should obey the law.&rdquo;</p>
<p>In San Diego, judges have ruled that building owners leasing to medical marijuana dispensaries can evict their tenants because collectives are illegal under the city&rsquo;s zoning laws and that the city may restrict the location of medical marijuana dispensaries based on those laws.</p>
<p>Collectives have been in legal limbo since officials three years ago determined that they didn&rsquo;t fit within any of the existing zones and therefore would not be issued a business license. The City Council approved an ordinance that outlined where dispensaries could operate, but that was repealed last summer after a successful referendum signature drive.</p>
<p>Last month, the state Supreme Court voted unanimously to review how cities and counties regulate medical marijuana dispensaries. Specifically, the court agreed to address whether municipalities can ban collectives despite the 1996 passage of Proposition 215.</p>
<p>A Los Angeles-based appellate court last year struck down Long Beach&rsquo;s attempt to license pot stores, ruling the local ordinance conflicted with federal law. Another appellate court upheld Riverside&rsquo;s right to close and prohibit dispensaries despite Proposition 215.</p>
<p>Since then, several cities &mdash; including Long Beach &mdash; have shuttered clubs or banned them from their boundaries. Other cities, such as San Francisco, suspended issuing permits because of the rulings.</p>
<p>Now that the Supreme Court has agreed to review the case, those appellate rulings are no longer valid.</p>
<p>The Associated Press contributed to this report.</p>
]]></content></entry><entry><title>Medical Marijuana for AARP Bulletin</title><category term="MEDICAL MARIJUANA"/><category term="aarp"/><category term="cancer treatment"/><category term="elder marijuana"/><category term="law"/><category term="legal cannabis institute"/><category term="matt slaby"/><category term="michelle diament"/><category term="nicole scott"/><category term="terminal"/><id>http://www.lcitraining.com/journal/2012/2/7/medical-marijuana-for-aarp-bulletin.html</id><link rel="alternate" type="text/html" href="http://www.lcitraining.com/journal/2012/2/7/medical-marijuana-for-aarp-bulletin.html"/><author><name>Legal Cannabis Institute</name></author><published>2012-02-08T06:05:13Z</published><updated>2012-02-08T06:05:13Z</updated><content type="html" xml:lang="en-US"><![CDATA[<div id="aarp_main_n_textimage" class="textImage">
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<p id="cq-gen3608">When Robert Jones, 70, was diagnosed with&nbsp;<a href="http://healthtools.aarp.org/learning-center/cancer">cancer</a>&nbsp;in 2007, he found little relief for the pain that came with his intensive chemotherapy treatments. That is, until his doctor prescribed&nbsp;<a href="http://www.aarp.org/health/conditions-treatments/info-10-2010/older_americans_increasingly_using_medical_marijuana_to_combat_nausea_pain.html">medical marijuana</a>, which not only eased the pain, but also helped to improve his appetite and limit anxiety.</p>
<p id="cq-gen3610">Today, though Jones&#8217; cancer is in remission, he continues to use marijuana to stem the lingering effects of the illness. But he recently learned that the treatment could cost him his home.</p>
<p><span class="full-image-float-right ssNonEditable"><span><img style="width: 280px;" src="http://www.lcitraining.com/storage/0052.jpg?__SQUARESPACE_CACHEVERSION=1328682152632" alt="" /></span></span></p>
<p>In October, the Las Vegas, N.M., resident received a letter indicating that he would no longer be eligible for the federal housing voucher that helps cover his $400-a-month rent. The reason: Though Jones&#8217; use of medical marijuana is permitted in New Mexico, the drug is not legal at the federal level, wrote Gilbert Almanza Jr., executive director of the San Miguel County Section 8 Housing Program.</p>
<p>Jones appealed the decision, saying he didn&#8217;t know what he would do without the voucher. He worried that he would be forced to live in a nursing facility.<br /><br />And forgoing the marijuana was not an option. &#8220;This is a treatment recommended by my doctor, and it&#8217;s not completed yet,&#8221; Jones says.</p>
<p><span class="full-image-float-left ssNonEditable"><span><img style="width: 280px;" src="http://www.lcitraining.com/storage/0012.jpg?__SQUARESPACE_CACHEVERSION=1328682200445" alt="" /></span></span>But just six days before the termination was to take effect, Jones got a reprieve: The local county commission voted to rescind the notice and issue an apology.</p>
<p>Almanza and other county officials did not return calls requesting comment.<br /><br /><em>Michelle Diament is a frequent contributor to the</em>&nbsp;AARP Bulletin.</p>
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<p>See more amazing photos by Matt Slaby here:&nbsp;<a class="external" rel="nofollow" href="http://mattslaby.photoshelter.com/gallery/Archive-NM-Medical-Marijuana/G0000qH5IsmB92nE/" target="_blank">http://mattslaby.photoshelter.com/gallery/Archive-NM-Medical-Marijuana/G0000qH5IsmB92nE/</a></p>
]]></content></entry><entry><title>10 Reasons why you should grow your own medicine... Make it your New Year's Resolution!</title><category term="cannabis"/><category term="grow"/><category term="hydroponics"/><category term="indoor"/><category term="legal cannabis institute"/><category term="marijuana"/><category term="nicole scott"/><category term="norml"/><category term="oaksterdam"/><category term="weed"/><id>http://www.lcitraining.com/journal/2012/1/2/10-reasons-why-you-should-grow-your-own-medicine-make-it-you.html</id><link rel="alternate" type="text/html" href="http://www.lcitraining.com/journal/2012/1/2/10-reasons-why-you-should-grow-your-own-medicine-make-it-you.html"/><author><name>Legal Cannabis Institute</name></author><published>2012-01-02T22:39:23Z</published><updated>2012-01-02T22:39:23Z</updated><content type="html" xml:lang="en-US"><![CDATA[<p><span class="full-image-float-left ssNonEditable"><span><img src="http://www.lcitraining.com/storage/plantmarijuana-225x300.jpg?__SQUARESPACE_CACHEVERSION=1325613413460" alt="" /></span></span>1.) Its a great hobby. In fact, growing weed is more addictive than smoking it!<br /><a href="http://2.bp.blogspot.com/-kHfVyuo0FUM/TwDeFDelLZI/AAAAAAAAAfs/IqDnZQo_eo4/s1600/H1.jpg"></a><br />2.)&nbsp; Its easy. You plant a seed and watch it grow. A few months later you have great smoke. Actually there&rsquo;s a bit more to it than this, but check out number 10&nbsp;to learn all the basics.<br /><br />3.) Its cheap (er) .. until you get really into it and decide to invest in lots of equipment and do an all out hi-tech indoor grow with all the latest gizmos .. and if (when: like I said, growing weed is addictive) you do go down that route, make lots of lists of how x$ spent now will save y$ later and persuade the missus that its a great investment really &hellip;<br /><br />4.) Its self-sufficient, .. there&rsquo;s certainly something to be said for the idea of producing something yourself that will give you so much, from seed to smoke. Modern life may not enable you to grow your own veg and I wouldn&rsquo;t advise you to grow weed on an allotment, but you CAN grow your own smoke. You yourself and you.White Dwarf autoflower<br /><br />5.) Its organic (well it can easily be) and natural: use the power of the sun to free the weed.<br /><br />6.) Its high tech and complicated: harness hi-tech to produce the biggest juiciest buds.<br /><br />7.) It cuts out the dodgy middleman. After all why give your hard earned dollars to someone you&rsquo;d think twice about giving the price of a cup of coffee to just because your usual guy is &ldquo;out&rdquo; at the moment?<br /><br />8.) Join the club. You&rsquo;ll probably find that once you start growing you&rsquo;ll meet others who do too. Swapping stories and strains soon becomes commonplace. But WORD OF WARNING be VERY VERY CAREFUL who you talk to &hellip; Loose mouths sink ships and all that.<br /><br />9.) Its an act of de-criminalization. Think about it. If every smoker grew 3 plants for their own use, and every time a policeman busted them, they had to go through the same paperwork trail and costly court costs as they do for someone growing 50 or 200 plants, do you think they would bother? Time and time again? And again? Nope. Its called normalisation, there are many examples of cities where they simply give cautions or dismiss these &ldquo;small cases&rdquo;: it just costs too much in time and manpower for too little a result. Let the police prosecute real criminals and leave the smoker alone. Stand up for what you believe in and grow it yourself.<br /><br />10.) You can take our Personal Grow Program in one Saturday and start off the right way: informed, prepared and ready to succeed. We also offer discounted grow systems to get started with a big savings.</p>
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<p>&nbsp;Written by:&nbsp;<span class="vcard post-author">Eingestellt von&nbsp;<span class="fn">i_love_weed</span>&nbsp;</span><span class="post-timestamp">um and Nicole Scott</span></p>
]]></content></entry><entry><title>Prosecutors use dubious claims to attack collectives</title><category term="asa"/><category term="cannabis"/><category term="duffy"/><category term="dumanis"/><category term="goldsmith"/><category term="legal"/><category term="legal cannabis institute"/><category term="marijuana"/><category term="nicole scott"/><category term="san diego"/><id>http://www.lcitraining.com/journal/2011/10/31/prosecutors-use-dubious-claims-to-attack-collectives.html</id><link rel="alternate" type="text/html" href="http://www.lcitraining.com/journal/2011/10/31/prosecutors-use-dubious-claims-to-attack-collectives.html"/><author><name>Legal Cannabis Institute</name></author><published>2011-10-31T18:23:48Z</published><updated>2011-10-31T18:23:48Z</updated><content type="html" xml:lang="en-US"><![CDATA[<h4>CityBeat&#8217;s guide to cutting through the haze of medical-marijuana misinformation</h4>
<p><span id="author_Trans" class="author">By&nbsp;<a href="http://www.sdcitybeat.com/sandiego/by-author-317-1.html">Dave Maass</a></span></p>
<p>There&rsquo;s one question on the minds of most medical-marijuana patients and advocates right now: What the eff is Obama thinking?</p>
<p>In recent weeks, California&rsquo;s four U.S. attorneys, under the authority of Obama&rsquo;s Department of Justice, have launched a full-scale war on dispensaries in California. The attack is mostly legal in nature, starting with letters sent to dispensaries and property owners ordering them to shut down within 45 days. U.S. Attorney&nbsp;<a href="http://www.justice.gov/usao/cas/usattorney/index.html" target="_blank">Laura Duffy</a>, whose jurisdiction includes San Diego and Imperial counties, has been among the most vocal. Having previously worked with District Attorney Bonnie Dumanis to raid collectives in 2009, Duffy&rsquo;s now backing&nbsp;<a href="http://www.sandiego.gov/cityattorney/" target="_blank">San Diego City Attorney Jan Goldsmith</a>&nbsp;in his crusade to shut down San Diego&rsquo;s 150-plus collectives using the city&rsquo;s zoning rules.</p>
<p>We&rsquo;ve found that prosecutors are backing up their arguments not with verifiable facts, but, rather, scaremongering propaganda and fuzzy assumptions&mdash;which we will now debunk for you.</p>
<p><strong>Dispensaries are &lsquo;prohibited&rsquo; in San Diego</strong></p>
<p>Following a judge&rsquo;s decision to temporarily shut down the Oasis Herbal Center in City Heights, Goldsmith&rsquo;s office issued a press release claiming that the judge had made a &ldquo;sweeping statement&rdquo; that dispensaries are &ldquo;prohibited&rdquo; in San Diego. That doesn&rsquo;t exactly paint a full picture of the situation.</p>
<p>While the judge correctly noted that the zoning code does not permit dispensaries, the code doesn&rsquo;t expressly prohibit them, either. In fact, another part of the municipal code welcomes them.</p>
<p>San Diego&rsquo;s Health and Sanitation Code states that the city&rsquo;s goal is to &ldquo;promote and protect the public health, safety and welfare of the citizens of San Diego by allowing and strictly regulating the cooperative cultivation and exchange of marijuana&rdquo; and includes a long list of rules for how collectives may operate.</p>
<p><span class="full-image-float-left ssNonEditable"><span><img style="width: 400px;" src="http://www.lcitraining.com/storage/janrampage.widea.jpg?__SQUARESPACE_CACHEVERSION=1320086245922" alt="" /></span></span>District Attorney Bonnie Dumanis, U.S. Attorney Laura Duffy and City Attorney Jan Goldsmith are blazing. - Photo illustration by Adam Vieyra</p>
<p>The problem is that the code also requires collectives to carry business permits, which they haven&rsquo;t been able to do since July 2009. That&rsquo;s when Development Services Director Kelly Broughton decided to stop issuing permits to dispensaries because he couldn&rsquo;t find a proper category for them. The city attempted to pass a zoning law, but medical-marijuana advocates thought it was too restrictive and collected enough signatures for a referendum. The City Council then repealed the measure to avoid a costly special election.</p>
<p>But zoning issues aren&rsquo;t what led the judge to shut down the Oasis collective. The judge said the primary reason was that Oasis was operating within 600 feet of a school, which is prohibited under state law.</p>
<p><strong>&lsquo;Magnets&rsquo; for crime</strong></p>
<p>Prosecutors have begun cultivating a perception that dispensaries are &ldquo;magnets&rdquo; for crime, often soliciting state ments from law-enforcement officers that aren&rsquo;t always grounded in facts.</p>
<p>Take, for example, 4015-4009 Park Blvd., a building in University Heights that housed as many as seven collectives and was one of the first sued by the city attorney. A San Diego police officer gave sworn testimony that he&rsquo;d observed an uptick in &ldquo;calls for service&rdquo; nearby and submitted seven pages of call logs to back it up.&nbsp;CityBeat&nbsp;analyzed the data and found there was no consistent trend in the calls&mdash; up, down or otherwise&mdash;and that the officer hadn&rsquo;t filtered the calls for relevancy. Requests for tow trucks and routine traffic stops inflated the numbers substantially. The officer also told the court that he&rsquo;d witnessed what &ldquo;appeared&rdquo; to be a pimp with his prostitutes outside the building, waiting to buy marijuana. His evidence: The women were &ldquo;scantily dressed&rdquo; and carrying their high heels.</p>
<p>Using official regional&nbsp;<a href="http://www.crimemapping.com/" target="_blank">crime-mapping software</a>, we found that only&nbsp;<a href="http://www.crimemapping.com/advancedTrendReport.aspx?db=4/18/2011%2000:00:00&amp;de=10/14/2011%2023:59:00&amp;ccs=AR,AS,BU,DP,DR,DU,FR,HO,VT,RO,SX,TH,VA,VB,WE&amp;add=4015%20Park%20Blvd,%20San%20Diego,%20CA%2092103&amp;bcy=3862252.4106389047&amp;bcx=-13040657.449120622&amp;br=0.094696&amp;xmin=-13041592.011224214&amp;ymin=3861853.5062806555&amp;xmax=-13039702.583431449&amp;ymax=3862466.1968354527&amp;faid=137a7b29-7112-471f-9d43-728ca7ec478f" target="_blank">11 crimes</a>&nbsp;were reported within 500 feet of the building in the last six months&mdash;a number that&rsquo;s unremarkable compared with levels in other areas in the community. Nine times that amount of crime has occurred<a href="http://www.crimemapping.com/advancedTrendReport.aspx?db=4/18/2011%2000:00:00&amp;de=10/14/2011%2023:59:00&amp;ccs=AR,AS,BU,DP,DR,DU,FR,HO,VT,RO,SX,TH,VA,VB,WE&amp;add=1010%20University%20Ave,%20San%20Diego,%20CA%2092103&amp;bcy=3861972.925745819&amp;bcx=-13041632.46910447&amp;br=0.094696&amp;xmin=-13042577.183000833&amp;ymin=3861748.990522475&amp;xmax=-13040687.755208068&amp;ymax=3862196.8637350453&amp;faid=137a7b29-7112-471f-9d43-728ca7ec478f" target="_blank">within 500 feet</a>&nbsp;of the Gila Rut Aveda Salon (run by Duffy&rsquo;s wife) a half-mile away.</p>
<p>Maybe curlers attract crime, too.&nbsp;</p>
<p><strong>The big marijuana industry</strong></p>
<p>At a recent press conference outlining the crackdown, Duffy described marijuana as fueling a &ldquo;pervasive, for-profit&rdquo; marijuana industry that&rsquo;s &ldquo;not about providing medicine to the sick.&rdquo; She&rsquo;s partially right.</p>
<p>If dispensaries employ at least five people each (a rough average), then it&rsquo;s possible that San Diego could abruptly lose a thousand jobs overnight. The marijuana industry extends well beyond the storefronts. The market, estimated to be somewhere between $1 billion and $1.5 billion in California, has provided tenants for landlords whose properties might otherwise sit empty, and the trickle-down revenue has flowed to a variety of complementary businesses, including hydroponics supply shops, doctors, lawyers, security firms and media outlets&mdash;such asCityBeat&mdash;that&nbsp;accept ads for all of the above.</p>
<p>Several pieces of bipartisan legislation are moving through Congress to further legitimize the marijuana industry, including bills to allow collectives to make standard business deductions and work with banks.</p>
<p>As for the other part&mdash;it&rsquo;s easy to say it&rsquo;s not about providing medicine if you don&rsquo;t believe it&rsquo;s medicine to begin with.</p>
<p><strong>&lsquo;No medicinal value&rsquo;</strong></p>
<p>This past June, the Drug Enforcement Administration (DEA) rejected a request by a pro-medi-pot group to remove marijuana from the list of drugs considered to have no medicinal value. But is the DEA&rsquo;s position supported by medical experts?</p>
<p>Created by the California Legislature in 1999 to answer the question, &ldquo;Does marijuana have therapeutic value?&rdquo; the&nbsp;<a href="http://www.cmcr.ucsd.edu/" target="_blank">Center for Medicinal Cannabis Research</a>&nbsp;(CMCR) at UCSD has spent the last decade studying marijuana&rsquo;s medicinal efficacy. In a February 2010 report to the Legislature, CMCR said that its researchers had found, after five clinical trials, there was &ldquo;reasonable evidence&rdquo; that cannabis can help folks suffering from pain and diseases of the nervous system, though more research is needed.</p>
<p>Two weeks ago, at its annual meeting, the California Medical Association released&nbsp;<a href="http://www.cmanet.org/files/pdf/news/cma-cannabis-tac-white-paper-101411.pdf" target="_blank">a report</a>&nbsp;saying basically the same thing: Studies completed so far are promising but few, and the feds need to reschedule cannabis &ldquo;to encourage research lending to responsible regulation.&rdquo; In addition, the CMA report calls the criminalization of marijuana &ldquo;a failed public health policy&rdquo; that leads to unregulated use and diverts money away from vital health, education and transportation programs.</p>
<p><strong>They&rsquo;re selling to kids and junkies!</strong></p>
<p>There&rsquo;s a difference between &ldquo;children&rdquo; and &ldquo;minors.&rdquo; When it comes to marijuana, the feds refer to anyone younger than 21 as a minor, while the city&rsquo;s collective ordinance considers minors to be younger than 18&mdash;those younger than 18 can access marijuana only with parental consent.</p>
<p>A&nbsp;CityBeat&nbsp;reporter has visited numerous dispensaries around town; in every case, someone at the door has checked IDs to keep minors out.CityBeat&nbsp;can also attest that medical-marijuana patients exist in all levels of societal strata&mdash;they include business owners, prominent attorneys, media professionals and senior staff at City Hall.</p>
<p>The district attorney&rsquo;s most recent statistics&mdash;published in 2006 but still circulated today by anti-pot advocates&mdash;found that the under-21 demographic accounted for only 12 percent of marijuana dispensary customers. On the other hand, patients older than 30 accounted for 43 percent.</p>
<p>One may well ask whether the remaining 40 percent of patients who are in their 20s are using it recreationally. That&rsquo;s the healthiest age group, so they can&rsquo;t all be suffering from cancer, AIDS or other debilitating diseases, right? Right&mdash;it&rsquo;s true that some &ldquo;patients&rdquo; use medical marijuana recreationally. But consider this: Young adults in their 20s are the largest uninsured population in the U.S. It stands to reason that young adults would be more likely to experiment with marijuana as a medication rather than paying out of pocket to see a doctor.</p>
<p><strong>Prosecutors go after only the bad ones<span class="full-image-float-right ssNonEditable"><span><img src="http://www.lcitraining.com/storage/UTI1604128_t352.jpg?__SQUARESPACE_CACHEVERSION=1320086381728" alt="" /></span></span><br /></strong></p>
<p><a href="https://twitter.com/#!/ryantrabuco" target="_blank">Ryan Trabuco</a>, a member of the San Diego County Alcohol and Drug Advisory Board, once asserted on Twitter that if a collective was raided, then it must&rsquo;ve been doing something wrong because it wouldn&rsquo;t have been raided otherwise. That&rsquo;s a circular fallacy. What&rsquo;s worse is that it ignores the record.</p>
<p>Perhaps the most prominent case in San Diego involved a Vista collective operator, James Stacy, who was doing all the right things to stay consistent with California law. He hosted farmers markets to connect growers directly to patients and allowed patients to trade labor for medicine. However, of the 14 collectives busted in 2009, his was one of the few to end up in federal court. After more than a year of pre-trial maneuvering, he was offered a plea deal in which the U.S. attorney could claim a conviction but Stacy would be essentially let off the hook, with no jail time.</p>
<p>Stacy&rsquo;s not the only one: In the case of Eugene Davidovich, the San Diego Police Department had to return his marijuana after his acquittal for possession with intent to distribute. Jovan Jackson, who ran another collective, was also acquitted when a jury found the district attorney&rsquo;s argument lacked sufficient legal clarity.</p>
<p>That&rsquo;s not to say there aren&rsquo;t bad actors raking in huge sums from collectives and laundering it through a variety of nefarious schemes. A case unsealed recently by Duffy&rsquo;s office involving Club One Collective in San Marcos and Extreme Holistic Care in Wildomar shows significant evidence of the collectives&rsquo; operators moving huge sums of money among personal bank accounts. The defendant had already been busted once in 2007, according to&nbsp;<a href="http://www.nctimes.com/news/local/article_76fd92d5-e39c-535f-9289-7582148325c2.html" target="_blank">North County Times</a>,&nbsp;for being $430,000 delinquent on his state taxes.</p>
<p><strong>Collectives are going to shut down</strong></p>
<p>The U.S. attorney has sent hundreds of letters to collective operators and property owners (and even to people who haven&rsquo;t been engaged in either for a long time) giving them 45 days to shut down.</p>
<p>So, will they? Many have&mdash;some calling in to report their closure as we write this. Yet, as&nbsp;CityBeat&nbsp;columnist John R. Lamb&nbsp;<a href="http://www.sdcitybeat.com/sandiego/article-9658-is-laura-duffy-barki.html" target="_blank">reported</a>&nbsp;last week, former Medical Marijuana Task Force chair and Thomas Jefferson School of Law professor Alex Kreit believes that there&rsquo;s no way Duffy&rsquo;s office can follow through on her threats. Supporting that statement, attorney&nbsp;<a href="http://www.lrogerslaw.com/" target="_blank">Lance Rogers</a>&nbsp;says two of his clients have closed, but at least three plan to stay open. A large-scale lawsuit against the federal government on the behalf of collectives is expected to be filed within the next few weeks.</p>
<p>Nevertheless, marijuana advocates tell us that patients should begin stocking up in early November.</p>
<p>&nbsp;</p>
]]></content></entry><entry><title>Patient Advocates Sue Obama Justice Department Over Medical Marijuana Crackdown</title><category term="americans for safe access"/><category term="asa"/><category term="cannabis"/><category term="class"/><category term="law"/><category term="marijuana"/><category term="pot"/><category term="school"/><category term="training"/><category term="university"/><id>http://www.lcitraining.com/journal/2011/10/31/patient-advocates-sue-obama-justice-department-over-medical.html</id><link rel="alternate" type="text/html" href="http://www.lcitraining.com/journal/2011/10/31/patient-advocates-sue-obama-justice-department-over-medical.html"/><author><name>Legal Cannabis Institute</name></author><published>2011-10-31T18:03:27Z</published><updated>2011-10-31T18:03:27Z</updated><summary type="html" xml:lang="en-US"><![CDATA[ASA argues in its lawsuit that the Obama Justice Department (DOJ) has &#8220;instituted a policy to dismantle the medical marijuana laws of the State of California and to coerce its municipalities to pass bans on medical marijuana dispensaries.&#8221;
]]></summary></entry><entry><title>Patient Advocates Accuse Obama of Hypocritical, Aggressive Policy on Medical Marijuana</title><category term="americans for safe access"/><category term="asa"/><category term="california law"/><category term="education"/><category term="eugene"/><category term="marijuana"/><category term="norml"/><category term="san diego"/><id>http://www.lcitraining.com/journal/2011/10/7/patient-advocates-accuse-obama-of-hypocritical-aggressive-po.html</id><link rel="alternate" type="text/html" href="http://www.lcitraining.com/journal/2011/10/7/patient-advocates-accuse-obama-of-hypocritical-aggressive-po.html"/><author><name>Legal Cannabis Institute</name></author><published>2011-10-07T19:43:49Z</published><updated>2011-10-07T19:43:49Z</updated><content type="html" xml:lang="en-US"><![CDATA[<div>
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<div class="uiAttachmentTitle"><strong><a rel="nofollow" href="http://www.AmericansForSafeAccess.org/downloads/US_Attorney_Landlord_Letter.pdf" target="_blank"><span>http://www.AmericansForSafeAcc</span><span>ess.org/downloads/US_Attorney_</span>Landlord_Letter.pdf</a></strong></div>
<span class="caption"><a rel="nofollow nofollow" href="http://www.AmericansForSafeAccess.org/" target="_blank">www.AmericansForSafeAccess.org</a></span></div>
</div>
]]></content></entry><entry><title>Feds seek closure of medical pot dispensaries</title><category term="dispensaries"/><category term="dispensary"/><category term="lance rogers"/><category term="land lord"/><category term="law"/><category term="marijuana"/><category term="norml"/><category term="oaksterdam"/><category term="pot school"/><category term="weedfederal law"/><id>http://www.lcitraining.com/journal/2011/10/6/feds-seek-closure-of-medical-pot-dispensaries.html</id><link rel="alternate" type="text/html" href="http://www.lcitraining.com/journal/2011/10/6/feds-seek-closure-of-medical-pot-dispensaries.html"/><author><name>Legal Cannabis Institute</name></author><published>2011-10-07T02:44:41Z</published><updated>2011-10-07T02:44:41Z</updated><summary type="html" xml:lang="en-US"><![CDATA[Goldsmith said he plans to bring most, if not all, of the remaining dispensaries before the court, arguing they violate local zoning laws. The flow of legal action is expected to continue with another batch of lawsuits on Friday, a spokesman for the City Attorney’s Office said.
]]></summary></entry><entry><title>A dozen pot dispensaries to shut down</title><category term="class"/><category term="collective"/><category term="cooperative"/><category term="dispensaries"/><category term="dispensary"/><category term="education"/><category term="marijuana"/><category term="ordinance"/><category term="pot"/><category term="pot shop"/><category term="san diego"/><category term="training"/><id>http://www.lcitraining.com/journal/2011/10/6/a-dozen-pot-dispensaries-to-shut-down.html</id><link rel="alternate" type="text/html" href="http://www.lcitraining.com/journal/2011/10/6/a-dozen-pot-dispensaries-to-shut-down.html"/><author><name>Legal Cannabis Institute</name></author><published>2011-10-06T18:40:57Z</published><updated>2011-10-06T18:40:57Z</updated><summary type="html" xml:lang="en-US"><![CDATA[“Marijuana advocates and their lawyers have been wrong to assume that federal and local laws could be ignored and that cities like San Diego could be strong-armed into looking the other way,” he said in the statement. “Our job is to enforce the law and we will do it.”
]]></summary></entry><entry><title>Cannabis and Driving: A Scientific and Rational Review</title><category term="Paul Armentano"/><category term="education"/><category term="lcitraining"/><category term="legal cannabis institute"/><category term="marijuana"/><category term="nicole scott"/><category term="norml"/><category term="training"/><category term="university"/><category term="weed"/><id>http://www.lcitraining.com/journal/2011/9/25/cannabis-and-driving-a-scientific-and-rational-review.html</id><link rel="alternate" type="text/html" href="http://www.lcitraining.com/journal/2011/9/25/cannabis-and-driving-a-scientific-and-rational-review.html"/><author><name>Legal Cannabis Institute</name></author><published>2011-09-26T00:35:29Z</published><updated>2011-09-26T00:35:29Z</updated><content type="html" xml:lang="en-US"><![CDATA[<p>By&nbsp;<a href="mailto:paul@norml.org">Paul Armentano</a><br />September 12, 2011</p>
<p>Policy debates regarding marijuana law reform invariably raise the question: &#8220;How does society address concerns regarding cannabis consumption and driving?&#8221; The subject is worthy of serious discussion. NORML&#8217;s Board of Directors addressed this issue by ratifying a &#8220;no driving&#8221; clause to the organization&#8217;s &#8220;Principles of Responsible Cannabis Use&#8221;<a id="b1" name="b1"></a><a class="footnote" href="http://www.norml.org/index.cfm?Group_ID=7459#1">[1]</a>&nbsp;stating, &#8220;Although cannabis is said by most experts to be safer with motorists than alcohol and many prescription drugs, responsible cannabis consumers never operate motor vehicles in an impaired condition.&#8221;</p>
<p>Nevertheless, questions remain regarding the degree to which cannabis intoxication impairs actual driving performance. Unlike alcohol, which is known to increase drivers&#8217; risk-taking behavior and is a primary contributor in on-road accidents, marijuana&#8217;s acute impact on psychomotor skills is subtle and its real-world impact in automobile crashes is inconclusive.</p>
<p><strong>Drugged Driving: True Threat Or False Panic?</strong></p>
<p><span class="full-image-float-left ssNonEditable"><span><img style="width: 250px;" src="http://www.lcitraining.com/storage/motive_hemp_car_lightens_load.jpg?__SQUARESPACE_CACHEVERSION=1316998003349" alt="" /></span></span>Survey data indicates that approximately 112 million Americans (46 percent of the US population) have experimented with the use of illicit substances.<a id="b2" name="b2"></a><a class="footnote" href="http://www.norml.org/index.cfm?Group_ID=7459#2">[2]</a>&nbsp;Of these, more than 20 million (8.3 percent of the population) self-identify as &#8220;current&#8221; or &#8220;monthly&#8221; users of illicit drugs,<a id="b3" name="b3"></a><a class="footnote" href="http://www.norml.org/index.cfm?Group_ID=7459#3">[3]</a>&nbsp;and more than 10 million Americans say that they&#8217;ve operated a motor vehicle while under the influence of an illicit substance in the past year.<a id="b4" name="b4"></a><a class="footnote" href="http://www.norml.org/index.cfm?Group_ID=7459#4">[4]</a>&nbsp;These totals, while far from negligible, suggest that the prevalence of illicit drug use among US drivers is far less than the prevalence of alcohol among this same population.<a id="b5" name="b5"></a><a class="footnote" href="http://www.norml.org/index.cfm?Group_ID=7459#5">[5]</a></p>
<p>To date, &#8220;[The] role of [illicit] drugs as a causal factor in traffic crashes involving drug-positive drivers is still not well understood.&#8221;<a id="b6" name="b6"></a><a class="footnote" href="http://www.norml.org/index.cfm?Group_ID=7459#6">[6]</a>&nbsp;While some studies have indicated that illicit drug use is associated with an increased risk of accident, a relationship has not yet been clearly established regarding the use of psychoactive substances and crash severity.<a id="b7" name="b7"></a><a class="footnote" href="http://www.norml.org/index.cfm?Group_ID=7459#7">[7]</a>&nbsp;Some reviews of traffic fatality data indicate that, in general, drivers with the presence of illicit drugs in their system possess an enhanced fatality risk compared to sober drivers. However, this risk is far lower than the fatality risk associated with drivers who operate a vehicle with the presence of alcohol in their system above or near the legal limit for intoxication.<a id="b8" name="b8"></a><a class="footnote" href="http://www.norml.org/index.cfm?Group_ID=7459#8">[8]</a>&nbsp;According to one review of the literature: &#8220;The risk of all drug-positive drivers compared to drug-free drivers is similar to drivers with a blood alcohol concentration of 0.05%. The risk is also similar to drivers above age 60 compared to younger drivers [around age 35].&#8221;<a id="b9" name="b9"></a><a class="footnote" href="http://www.norml.org/index.cfm?Group_ID=7459#9">[9]</a></p>
<p>Marijuana is the most common illicit substance consumed by persons who report driving after drug use.<a id="b10" name="b10"></a><a class="footnote" href="http://www.norml.org/index.cfm?Group_ID=7459#10">[10]</a>&nbsp;Epidemiological research also indicates that cannabis is the most prevalent illicit drug detected in fatally injured drivers and motor vehicle crash victims.<a id="b11" name="b11"></a><a class="footnote" href="http://www.norml.org/index.cfm?Group_ID=7459#11">[11]</a>&nbsp;Reasons for this fact are twofold. One, cannabis is by far the most widely used illicit drug among the US population, with nearly one out of two Americans admitting having tried it.<a id="b12" name="b12"></a><a class="footnote" href="http://www.norml.org/index.cfm?Group_ID=7459#12">[12]</a>&nbsp;Two, marijuana is the most readily detectable illicit drug in toxicological tests. Marijuana&#8217;s primary psychoactive compound, THC, may accumulate and be detected in blood for several hours in occasional users; in some chronic users, THC may be present in blood for a period of days after past use,<a id="b13" name="b13"></a><a class="footnote" href="http://www.norml.org/index.cfm?Group_ID=7459#13">[13-15]</a>&nbsp;long after any performance impairing effects have worn off.<a id="b16" name="b16"></a><a class="footnote" href="http://www.norml.org/index.cfm?Group_ID=7459#16">[16]</a>&nbsp;In addition, non-psychoactive byproducts of cannabis, known as metabolites, may be detected in the urine of regular users for days or weeks after past use.<a id="b17" name="b17"></a><a class="footnote" href="http://www.norml.org/index.cfm?Group_ID=7459#17">[17]</a>&nbsp;(Other common illicit substances, such as cocaine or methamphetamine, do not possess such long half-lives.) Therefore, the substance&#8217;s prevalence in toxicological evaluations of US drivers does not necessarily indicate that it is a frequent or significant causal factor in auto accidents. In fact, states that have experienced a significant increase in the total number of authorized medical cannabis users have in general experienced no proportional corresponding rise in traffic fatalities, and most have experienced a decline in overall fatal accidents.<a id="b18" name="b18"></a><a class="footnote" href="http://www.norml.org/index.cfm?Group_ID=7459#18">[18]</a></p>
<p><strong>Cruising On Cannabis: Clarifying The Debate</strong></p>
<p>While it is well established that alcohol consumption increases accident risk, evidence of marijuana&#8217;s culpability in on-road driving accidents and injury is far less clear. Although acute cannabis intoxication following inhalation has been shown to mildly impair psychomotor skills, this impairment is seldom severe or long lasting.<a id="b19" name="b19"></a><a class="footnote" href="http://www.norml.org/index.cfm?Group_ID=7459#19">[19-20]</a>&nbsp;(By contrast, virtually no published research exists assessing the oral ingestion of cannabis edibles on psychomotor performance). In closed course and driving simulator studies, marijuana&#8217;s acute effects on psychomotor performance include minor impairments in tracking (eye movement control) and reaction time (break latency), as well as variation in lateral positioning (weaving), headway (drivers under the influence of cannabis tend to follow less closely to the vehicle in front of them), and speed (drivers tend to decrease speed following cannabis inhalation).<a id="b21" name="b21"></a><a class="footnote" href="http://www.norml.org/index.cfm?Group_ID=7459#21">[21]</a>&nbsp;Notably, these impairments in performance are more likely to be manifested in driver simulator tests than in assessments of actual on-road behavior, where changes in performance are consistently nominal.<a id="b22" name="b22"></a><a class="footnote" href="http://www.norml.org/index.cfm?Group_ID=7459#22">[22]</a>&nbsp;For example, A 2001 study evaluating the impact of marijuana intoxication on driving proficiency on city streets among sixteen subjects reported essentially no differences in subjects&#8217; driving performance after cannabis administration, concluding: &#8220;Performance as rated on the Driving Proficiency Scale did not differ between treatments. It was concluded that the effects of low doses of THC &#8230; on higher-level driving skills as measured in the present study are minimal.&#8221;<a id="b23" name="b23"></a><a class="footnote" href="http://www.norml.org/index.cfm?Group_ID=7459#23">[23]</a>&nbsp;Similarly, a 1993 trial funded by the United States National Highway Traffic Association (NTHSA) evaluated subjects&#8217; driving performance after cannabis inhalation in high-density urban traffic. Investigators reported, &#8220;Marijuana &#8230; did not significantly change mean driving performance.&#8221;<a id="b24" name="b24"></a><a class="footnote" href="http://www.norml.org/index.cfm?Group_ID=7459#24">[24]</a></p>
<p>In general, cannabis-induced variations in driving behavior, when present, are less consistent or pronounced than the impairments exhibited by subjects under the influence of alcohol.<a id="b25" name="b25"></a><a class="footnote" href="http://www.norml.org/index.cfm?Group_ID=7459#25">[25]</a>&nbsp;Unlike subjects impaired by alcohol, individuals under the influence of cannabis tend to be aware of their impairment and try to compensate for it accordingly, either by driving more cautiously<a id="b26" name="b26"></a><a class="footnote" href="http://www.norml.org/index.cfm?Group_ID=7459#26">[26]</a>&nbsp;or by expressing an unwillingness to drive altogether.<a id="b27" name="b27"></a><a class="footnote" href="http://www.norml.org/index.cfm?Group_ID=7459#27">[27]</a>&nbsp;Further, numerous studies report that experienced cannabis users develop tolerance to many of the changes in cognitive or psychomotor performance associated with acute cannabis intoxication.<a id="b28" name="b28"></a><a class="footnote" href="http://www.norml.org/index.cfm?Group_ID=7459#28">[28-30]</a>&nbsp;Most recently, a 2010 double-blind, placebo-controlled study of 21 heavy cannabis users assessed the impact of alcohol or THC inhalation on measures of perceptual motor control (critical tracking task), dual task processing (divided-attention task), motor inhibition (stop-signal task), and cognition (Tower of London). Authors reported: &#8220;Alcohol significantly impaired critical tracking, divided attention, and stop-signal performance. THC generally did not affect task performance.&#8221; They concluded, &#8220;[T]he present study generally confirms that heavy cannabis users develop tolerance to the impairing effects of THC on neurocognitive task performance.&#8221;<a id="b31" name="b31"></a><a class="footnote" href="http://www.norml.org/index.cfm?Group_ID=7459#31">[31]</a></p>
<p>As a result, cannabis-induced variations in performance do not typically appear to play a significant role in on-road traffic accidents when the THC levels present in a driver&#8217;s blood are low and/or cannabis is not consumed in combination with alcohol.<a id="b32" name="b32"></a><a class="footnote" href="http://www.norml.org/index.cfm?Group_ID=7459#32">[32-33]</a>&nbsp;For example, a 1993 National Highway Traffic Safety Administration review of the role of drug use in fatal accidents reported, &#8220;[T]here is little if any evidence to indicate that drivers who have used marijuana alone are any more likely to cause serious accidents than drug free drivers.&#8221;<a id="b34" name="b34"></a><a class="footnote" href="http://www.norml.org/index.cfm?Group_ID=7459#34">[34]</a>&nbsp;A more recent assessment by Blows and colleagues noted that self-reported recent use of cannabis (within three hours of driving) was not significantly associated with car crash injury after investigators controlled for specific cofounders (e.g., seat-belt use, sleepiness, etc.)<a id="b35" name="b35"></a><a class="footnote" href="http://www.norml.org/index.cfm?Group_ID=7459#35">[35]</a>&nbsp;A 2004 observational case control study published in the journal<em>&nbsp;Accident, Analysis and Prevention</em>reported that only drivers under the influence of alcohol or benzodiazepines experience an increased crash risk compared to drug-free controls. Investigators did observe increased risks &ndash; though they were not statistically significant &ndash; among drivers using amphetamines, cocaine and opiates, but found, &#8220;No increased risk for road trauma was found for drivers exposed to cannabis.&#8221;<a id="b36" name="b36"></a><a class="footnote" href="http://www.norml.org/index.cfm?Group_ID=7459#36">[36]</a></p>
<p>A limited number of more recent studies and reviews have postulated a positive association between presumed recent, dose-dependent cannabis exposure and a gradually increased risk of vehicle accident.<a id="b37" name="b37"></a><a class="footnote" href="http://www.norml.org/index.cfm?Group_ID=7459#37">[37-39]</a>&nbsp;However, this elevated risk was below the risk associated with drivers who had consumed even small quantities of alcohol.</p>
<p>A 2007 case-control study published in the&nbsp;<em>Canadian Journal of Public Health</em>reviewed 10-years of US auto-fatality data. Investigators found that US drivers with blood alcohol levels of 0.05% &ndash; a level well below the legal limit for intoxication &ndash; were three times as likely to have engaged in unsafe driving activities prior to a fatal crash as compared to individuals who tested positive for marijuana.<a id="b40" name="b40"></a><a class="footnote" href="http://www.norml.org/index.cfm?Group_ID=7459#40">[40]</a>&nbsp;A 2005 review of auto accident fatality data from France reported similar results, finding that drivers who tested positive for any amount of alcohol had a four times greater risk of having a fatal accident than did drivers who tested positive for marijuana in their blood.<a id="b41" name="b41"></a><a class="footnote" href="http://www.norml.org/index.cfm?Group_ID=7459#41">[41]</a>&nbsp;In the latter study, even drivers with low levels of alcohol present in their blood (below 0.05%) experienced a greater elevated risk as compared to drivers who tested positive for higher concentrations of cannabis (above 5ng/ml). Both studies noted that overall few traffic accidents appeared to be attributed to driver&#8217;s operating a vehicle while impaired by cannabis.</p>
<p><span class="full-image-float-right ssNonEditable"><span><img src="http://www.lcitraining.com/storage/norml_logo.gif?__SQUARESPACE_CACHEVERSION=1316998032274" alt="" /></span></span>Following the publication of these papers, various investigators have attempted to associate specific THC blood levels to driver impairment.<a id="b42" name="b42"></a><a class="footnote" href="http://www.norml.org/index.cfm?Group_ID=7459#42">[42-43]</a>&nbsp;However, there are many reasons why such an association should be interpreted with extreme caution. First, peak THC blood levels following inhalation do not consistently correspond with levels of peak impairment.<a id="b44" name="b44"></a><a class="footnote" href="http://www.norml.org/index.cfm?Group_ID=7459#44">[44]</a>&nbsp;(In fact, subjects who inhale THC typically ascertain their highest THC blood levels within minutes, well before the drug&#8217;s impairing effects have reached their peak.) As a result, it is virtually impossible to make inferences regarding a subject&#8217;s impairment based upon the presence of THC alone in a single sample.<a id="b45" name="b45"></a><a class="footnote" href="http://www.norml.org/index.cfm?Group_ID=7459#45">[45-46]</a></p>
<p>Second, cannabis&#8217; effect on psychomotor performance varies widely among individual subjects, particularly among those who are cannabis experienced versus those who are naive. As a result of these extreme variations, even experts who are on record in support of estimated blood/THC impairment standards acknowledge that such thresholds &#8220;are not necessarily applicable to each and every driver an individual.&#8221;<a id="b47" name="b47"></a><a class="footnote" href="http://www.norml.org/index.cfm?Group_ID=7459#47">[47]</a></p>
<p>Third, recent studies of chronic cannabis consumers indicate that residual levels of THC may be present in blood without associated impairment of performance for several days after past use.<a id="b48" name="b48"></a><a class="footnote" href="http://www.norml.org/index.cfm?Group_ID=7459#48">[48-49]</a>&nbsp;This accumulation of THC in chronic consumers &#8220;leads to cannabinoid concentrations in sober phases that resemble concentrations found in occasional users after acute cannabis use,&#8221;<a id="b50" name="b50"></a><a class="footnote" href="http://www.norml.org/index.cfm?Group_ID=7459#50">[50]</a>&nbsp;thus making the universal application of a specific blood/THC impairment standard inappropriate.</p>
<p>Finally, at this time there is no practical method for law enforcement officers at the scene to collect blood samples from suspected DUI cannabis drivers in a timely manner. This delay in collection (which may typically be as long as several hours), combined with the THC&#8217;s complex and inconsistent pharmacokinetics, make it impossible to infer whether, or to what extent, a subject was previously impaired based solely on a positive blood test result.<a id="b51" name="b51"></a><a class="footnote" href="http://www.norml.org/index.cfm?Group_ID=7459#51">[51]</a></p>
<p>For these reasons, NORML does not endorse the imposition of per se laws for drivers who test positive for THC in the blood without additional demonstrable evidence of psychomotor impairment. In particular, NORML opposes the imposition of so-called &#8216;zero tolerance&#8217; per se standards, which legally define a motorist impaired if he or she tests positive for the presence of any amount of THC or THC metabolite in their blood or urine.<a id="b52" name="b52"></a><a class="footnote" href="http://www.norml.org/index.cfm?Group_ID=7459#52">[52]</a></p>
<p><strong>Defining A Rational &#8216;Drugged Driving&#8217; Policy</strong></p>
<p>The above review illustrates the need for further education and understanding regarding the effects of cannabis upon driving behavior. While its adverse impact on psychomotor skills is less severe than the effects of alcohol, driving under the acute influence of cannabis still may pose an elevated risk of accident in certain situations, especially among inexperienced cannabis consumers. However, because marijuana&#8217;s psychomotor impairment is subtle and short-lived, consumers can greatly reduce this risk by refraining from driving for a period of several hours immediately following their cannabis use.</p>
<p>By contrast, motorists should never be encouraged to operate a vehicle while smoking cannabis. Drivers should also be advised that engaging in the simultaneous use of both cannabis and alcohol can in some instances significantly increase their risk of accident compared to the consumption of either substance alone.<a id="b53" name="b53"></a><a class="footnote" href="http://www.norml.org/index.cfm?Group_ID=7459#53">[53]</a>&nbsp;Past use of cannabis, as defined by the detection solely of inactive cannabis metabolites in the urine of drivers, is not associated with an increased accident risk.<a id="b54" name="b54"></a><a class="footnote" href="http://www.norml.org/index.cfm?Group_ID=7459#54">[54]</a></p>
<p>Educational or public service campaigns targeting drugged driving behavior should particularly be aimed toward the younger driving population age 18 to 25 &ndash; as this group is most likely use cannabis<a id="b55" name="b55"></a><a class="footnote" href="http://www.norml.org/index.cfm?Group_ID=7459#55">[55]</a>&nbsp;and report having operated a motor vehicle shortly after consuming pot.<a id="b56" name="b56"></a><a class="footnote" href="http://www.norml.org/index.cfm?Group_ID=7459#56">[56]</a>&nbsp;In addition, this population may have less driving experience, may be more prone to engage in risk-taking behavior, and may be more na&iuml;ve to pot&#8217;s psychoactivity as compared to older, more experienced populations who are more likely to be tolerant to the drug&#8217;s performance-impairing effects. This younger population also reports a greater likelihood for having driven after using cannabis in combinations with other illicit drugs or alcohol.<a id="b57" name="b57"></a><a class="footnote" href="http://www.norml.org/index.cfm?Group_ID=7459#57">[57]</a>&nbsp;Such an educational campaign<a id="b58" name="b58"></a><a class="footnote" href="http://www.norml.org/index.cfm?Group_ID=7459#58">[58]</a>&nbsp;was implemented nationwide in Canada by the Canadian Public Health Association and could readily be replicated in the United States. Arguably, such a campaign would enjoy enhanced credibility if coordinated by a private public health association or traffic safety organization, such as the American Public Health Association or the AAA Automobile Club, as opposed to the federal Office of National Drug Control Policy &ndash; whose previous public service campaigns have demonstrated limited influence among younger audiences.<a id="b59" name="b59"></a><a class="footnote" href="http://www.norml.org/index.cfm?Group_ID=7459#59">[59]</a>&nbsp;Most recently, the Colorado Department of Transportation launched its own &#8216;drugged driving awareness&#8217; campaign at the statewide level.<a id="b60" name="b60"></a><a class="footnote" href="http://www.norml.org/index.cfm?Group_ID=7459#60">[60]</a></p>
<p>&nbsp;</p>
<p>Finally, increased efforts should be made within the law enforcement community to train officers and DREs (drug recognition experts) to better identify drivers who may be operating a vehicle while impaired by marijuana. Changes may also be adopted to roadside Standardized Field Sobriety Test making these evaluations more sensitive to drivers who may be under the influence of cannabis. Preliminary scientific evaluations of these tests in controlled conditions have shown that subjects&#8217; performance during modified SFSTs may be positively associated with dose-related levels of marijuana impairment.<a id="b61" name="b61"></a><a class="footnote" href="http://www.norml.org/index.cfm?Group_ID=7459#61">[61]</a></p>
<p>Though the development of roadside cannabis-specific detection testing (similar to an alcohol breathalyzer test) is still in its infancy, an argument may be made for the provisional use of such tests by specially trained members of law enforcement. In addition, the development of point-of-collection cannabis-sensitive technology to rapidly identify the presence of THC in drivers, such as a roadside saliva test, would provide utility to law enforcement in their efforts to better identify suspected intoxicated drivers. The development of such technology would also increase public support for the taxation and regulation of cannabis by helping to assuage concerns that liberalizing marijuana policies could potentially lead to an increase in incidences of drugged driving.<a id="b62" name="b62"></a><a class="footnote" href="http://www.norml.org/index.cfm?Group_ID=7459#62">[62]</a>&nbsp;Such concerns are a significant impediment to the enactment of marijuana law reform, and arguably must be sufficiently addressed before a majority of the public will embrace any public policy that proposes regulating adult cannabis use like alcohol.</p>
<p>###</p>
<p><em><span class="full-image-float-right ssNonEditable"><span><img style="width: 220px;" src="http://www.lcitraining.com/storage/1697398896_bff10256f3.jpg?__SQUARESPACE_CACHEVERSION=1316997821537" alt="" /></span></span>Paul Armentano is the Deputy Director of NORML and the NORML Foundation. Mr. Armentano is a nationally recognized expert in the field of marijuana policy, health, pharmacology, and pharmacokinetics. He has attended various international conferences on the subject of cannabis and toxicology, including those sponsored by the Society of Forensic Toxicologists (SOFT), the American Academy of Forensic Sciences (AAFS), and The International Council on Alcohol, Drugs &amp; Traffic Safety (ICADTS). He has coordinated campaign and lobbying efforts in numerous states pertaining to drugged driving and he was an independent consultant on the Canadian Public Health Association&#8217;s &#8220;Pot and Driving&#8221; campaign, a project to increase awareness among young Canadians age 14 to 18 about the risks of cannabis-impaired driving. Mr. Armentano has authored peer-reviewed papers on the subject of marijuana, driving, and public policy, including most recently &#8217; Driving Under the Influence,&#8217; which appears in The Pot Book: A Complete Guide to Cannabis &ndash; It&#8217;s Role in Medicine, Politics, Science, and Culture (editor: Julie Holland, M.D., Park Street Press, 2010). He may be contacted via e-mail at:<a href="http://www.norml.org/paul@norml.org">paul@norml.org</a>.</em></p>
<p><em><br /></em></p>
<p class="smalltxt"><strong>Footnotes</strong></p>
<p class="smalltxt"><a id="1" name="1"></a><a href="http://www.norml.org/index.cfm?Group_ID=7459#b1">[1]</a>&nbsp;Adopted by NORML&#8217;s Board of Directors, February 3, 1996. Read all of NORML&#8217;s &#8220;<a href="http://www.norml.org/index.cfm?Group_ID=3417">Principles of Responsible Use</a>&#8221;</p>
<p class="smalltxt"><a id="2" name="2"></a><a href="http://www.norml.org/index.cfm?Group_ID=7459#b2">[2]</a>&nbsp;US Department of Justice, Bureau of Justice Statistics.&nbsp;<em>Drug and Crime Facts: Drug Use Among the General Population</em>. Online document accessed November 24, 2007.</p>
<p class="smalltxt"><a id="3" name="3"></a><a href="http://www.norml.org/index.cfm?Group_ID=7459#b3">[3]</a>&nbsp;US Department of Health and Human Services, Substance and Mental Health Services Association, Office of Applied Studies.&nbsp;<em><a href="http://www.oas.samhsa.gov/nsduh/2k6nsduh/2k6Results.cfm#Fig2-1" target="_blank">2006 National Survey on Drug Use and Health: National Results</a></em>. Online document accessed November 24, 2007.</p>
<p class="smalltxt"><a id="4" name="4"></a><a href="http://www.norml.org/index.cfm?Group_ID=7459#b4">[4]</a>&nbsp;Ibid.</p>
<p class="smalltxt"><a id="5" name="5"></a><a href="http://www.norml.org/index.cfm?Group_ID=7459#b5">[5]</a>&nbsp;US Department of Transportation, National Highway Traffic Safety Administration.<em>&nbsp;<a href="http://www.nhtsa.dot.gov/people/injury/research/StateofKnwlegeDrugs/StateofKnwlegeDrugs/" target="_blank">State of Knowledge of Drugged Driving: FINAL REPORT</a></em>. September 2003.</p>
<p class="smalltxt"><a id="6" name="6"></a><a href="http://www.norml.org/index.cfm?Group_ID=7459#b6">[6]</a>&nbsp;Ibid.</p>
<p class="smalltxt"><a id="7" name="7"></a><a href="http://www.norml.org/index.cfm?Group_ID=7459#b7">[7]</a>Smink et al. 2005. Drug use and the severity of traffic accident.&nbsp;<em>Accident, Analysis and Prevention</em>&nbsp;37: 427-433.</p>
<p class="smalltxt"><a id="8" name="8"></a><a href="http://www.norml.org/index.cfm?Group_ID=7459#b8">[8]</a>&nbsp;Franjo Grotenhermen.&nbsp;<em>Drugs and Driving: Review for the National Treatment Agency, UK</em>. Nova-Institut (Germany). November 2007.</p>
<p class="smalltxt"><a id="9" name="9"></a><a href="http://www.norml.org/index.cfm?Group_ID=7459#b9">[9]</a>&nbsp;Ibid.</p>
<p class="smalltxt"><a id="10" name="10"></a><a href="http://www.norml.org/index.cfm?Group_ID=7459#b10">[10]</a>&nbsp;US Department of Health and Human Services, Substance and Mental Health Services Association, Office of Applied Studies.&nbsp;<em><a href="http://www.oas.samhsa.gov/driverrprt/toc.htm" target="_blank">Driving After Drug or Alcohol Use, 1998</a></em>. Online document accessed November 24, 2007.</p>
<p class="smalltxt"><a id="11" name="11"></a><a href="http://www.norml.org/index.cfm?Group_ID=7459#b11">[11]</a>&nbsp;US Department of Transportation. 2003. op. cit.</p>
<p class="smalltxt"><a id="12" name="12"></a><a href="http://www.norml.org/index.cfm?Group_ID=7459#b12">[12]</a>&nbsp;October 23-24, 2002 CNN/Time poll conducted by Harris Interactive.</p>
<p class="smalltxt"><a id="13" name="13"></a><a href="http://www.norml.org/index.cfm?Group_ID=7459#b13">[13]</a>&nbsp;Skopp et al. 2003. Serum cannabinoid levels 24 to 48 hours after cannabis smoking<em>. Archives of Criminology</em>&nbsp;(Germany) 212: 83-95.</p>
<p class="smalltxt"><a href="http://www.norml.org/index.cfm?Group_ID=7459#b13">[14]</a>&nbsp;Toennes et al. 2008. Comparison of cannabinoid pharmacokinetic properties in occasional and heavy users smoking a marijuana or placebo joint. Journal of Analytical Toxicology 32: 470-477. &#8220;Heavy users might exhibit measurable cannabinoid concentrations in blood, even if the last cannabis use was more than 24 hours ago. This is due to redistribution from deep compartments and to the prolonged elimination of THC.&#8221;</p>
<p class="smalltxt"><a href="http://www.norml.org/index.cfm?Group_ID=7459#b13">[15]</a>&nbsp;Karschner et al. 2009. Do Delta- 9-tetrahydrocannabinol concentrations indicate recent use in chronic cannabis users? Addiction 104: 2041-2048. &#8220;Substantial whole blood THC concentrations persist multiple days after drug discontinuation in heavy chronic cannabis users.&#8221;</p>
<p class="smalltxt"><a id="16" name="16"></a><a href="http://www.norml.org/index.cfm?Group_ID=7459#b16">[16]</a>&nbsp;Ronen et al. 2007. Effects of THC on driving performance, physiological state and subjective feelings relative to alcohol. Accident, Analysis and Prevention 40: 926-934. &#8220;No THC effects were observed after 24 h on any of the measures.&#8221;</p>
<p class="smalltxt"><a id="17" name="17"></a><a href="http://www.norml.org/index.cfm?Group_ID=7459#b17">[17]</a>&nbsp;Musshoff and Madea. 2006. Review of biological matrices (urine, blood, and hair) as indicators of recent or ongoing cannabis use. Therapeutic Drug Monitor 28: 155-163.</p>
<p class="smalltxt"><a id="18" name="18"></a><a href="http://www.norml.org/index.cfm?Group_ID=7459#b18">[18]</a>&nbsp;<a href="http://www-fars.nhtsa.dot.gov/States/StatesFatalitiesFatalityRates.aspx" target="_blank">National Highway Traffic Safety Administration, Fatalities and Fatality Rates By State, 1994-2009</a>. Online document access September 6, 2011.</p>
<p class="smalltxt"><a id="19" name="19"></a><a href="http://www.norml.org/index.cfm?Group_ID=7459#b19">[19]</a>&nbsp;According to the US Department of Transportation, National Highway Traffic Safety Administration.&nbsp;<em>State of Knowledge of Drugged Driving: FINAL REPORT.&nbsp;</em>op. cit., &#8220;Experimental research on the effects of cannabis &#8230; indicat[e] that any effects &#8230; dissipate quickly after one hour.&#8221;</p>
<p class="smalltxt"><a href="http://www.norml.org/index.cfm?Group_ID=7459#b19">[20]</a>&nbsp;According to the 2004 National Highway Traffic Safety Administration factsheet, Drugs and Human Performance, peak acute effects are typically reached within 10 to 30 minutes after inhalation.</p>
<p class="smalltxt"><a id="21" name="21"></a><a href="http://www.norml.org/index.cfm?Group_ID=7459#b21">[21]</a>&nbsp;US Department of Transportation. National Highway Traffic Safety Administration. State of Knowledge of Drugged Driving: FINAL REPORT. op. cit. Other summaries include: Ramaekers et al. 2006. Cognition and motor control as a function of Delta-9-THC concentration in serum and oral fluid: Limits of impairment. Drug and Alcohol Dependence 85: 114-122; David Hadorn. &#8220;A Review of Cannabis and Driving Skills,&#8221; In: The Medicinal Uses of Cannabis and Cannabinoids. (eds: Guy et al). Pharmaceutical Press, 2004; Canadian Senate Special Committee on Illegal Drugs, Cannabis: Summary Report: Our Position for a Canadian Public Policy. 2002. (See specifically: Chapter 8: &#8220;Driving Under the Influence of Cannabis&#8221;); Alison Smiley. &#8220;Marijuana: On-Road and Driving-Simulator Studies,&#8221; In: The Health Effects of Cannabis. (eds. Kalant et al) Canadian Centre for Addiction and Mental Health, 1999.</p>
<p class="smalltxt"><a id="22" name="22"></a><a href="http://www.norml.org/index.cfm?Group_ID=7459#b22">[22]</a>&nbsp;US Department of Transportation, National Highway Traffic Safety Administration. Marijuana and Actual Driving Performance: Final Report. November 1993. &#8220;It appears performance is more affected by THC in laboratory (settings) than (in) actual driving tests.&#8221;</p>
<p class="smalltxt"><a id="23" name="23"></a><a href="http://www.norml.org/index.cfm?Group_ID=7459#b23">[23]</a>&nbsp;Lamers and Ramaekers. 2001. Visual search and urban driving under the influence of marijuana and alcohol. Human Psychopharmacology 16: 393-401.</p>
<p class="smalltxt"><a id="24" name="24"></a><a href="http://www.norml.org/index.cfm?Group_ID=7459#b24">[24]</a>&nbsp;US Department of Transportation, National Highway Traffic Safety Administration. Marijuana and Actual Driving Performance: Final Report. op. cit.</p>
<p class="smalltxt"><a id="25" name="25"></a><a href="http://www.norml.org/index.cfm?Group_ID=7459#b25">[25]</a>&nbsp;David Hadorn. 2004. op. cit. and US Department of Transportation. 2003. op. cit.</p>
<p class="smalltxt"><a id="26" name="26"></a><a href="http://www.norml.org/index.cfm?Group_ID=7459#b26">[26]</a>&nbsp;According to the US Department of Transportation, National Highway Traffic Safety Administration.&nbsp;<em>State of Knowledge of Drugged Driving: FINAL REPORT.</em>&nbsp;op. cit., &#8220;The extensive studies by Robbe and O&#8217;Hanlon (1993), revealed that under the influence of marijuana, drivers are aware of their impairment, and when the experimental task allows it, they tend to actually decrease speed, avoid passing other cars, and reduce other risk-taking behaviors.&#8221;</p>
<p class="smalltxt"><a id="27" name="27"></a><a href="http://www.norml.org/index.cfm?Group_ID=7459#b27">[27]</a>&nbsp;Menetrey et al. 2005. Assessment of driving capability through the use of clinical and psychomotor tests in relation to blood cannabinoid levels following oral administration of 20mg dronabinol or of a cannabis decoction made with 20 and 60mg delta-9-THC.&nbsp;<em>Journal of Analytical Toxicology</em>&nbsp;29: 327-338.</p>
<p class="smalltxt"><a id="28" name="28"></a><a href="http://www.norml.org/index.cfm?Group_ID=7459#b28">[28]</a>&nbsp;D&#8217;Souza et al. 2008. Blunted psychotomimetic and amnestic effects of delta-9-tetrahydrocannabinol in frequent users of cannabis. Neuropsychopharmacology 33: 2505-2016. &#8220;These data suggest that frequent users of cannabis are either inherently blunted in their response to, and/or develop tolerance to the psychotomimetic, perceptual altering, amnestic, endocrine, and other effects of cannabinoids.&#8221;</p>
<p class="smalltxt"><a href="http://www.norml.org/index.cfm?Group_ID=7459#b28">[29]</a>&nbsp;Ramaekers et al. 2009. Neurocognitive performance during acute THC intoxication in heavy and occasional cannabis users. Journal of Psychopharmacology 23: 266-277. &#8220;THC did not affect the performance of heavy cannabis users except in the stop signal task, i.e. stop reaction time increased, particularly at high THC concentrations. Group comparisons of overall performance in occasional and heavy users did not reveal any persistent performance differences due to residual THC in heavy users. These data indicate that cannabis use history strongly determines the behavioural response to single doses of THC.&#8221;</p>
<p class="smalltxt"><a href="http://www.norml.org/index.cfm?Group_ID=7459#b28">[30]</a>&nbsp;Hart et al. 2010. Neurophysiological and cognitive effects of marijuana in frequent users. 2010. Pharmacology, Biochemistry and Behavior 96: 333-341. &#8220;In summary, the current data suggest that frequent marijuana users may show fewer behavioral signs of disruption during intoxication than infrequent users, even when difficult memory tasks are used to assess cognitive performance. &#8230; These data emphasize the importance of taking into account the drug-use histories of research participants and examining multiple measures when investigating marijuana-related effects on cognitive functioning.&#8221;</p>
<p class="smalltxt"><a id="31" name="31"></a><a href="http://www.norml.org/index.cfm?Group_ID=7459#b31">[31]</a>&nbsp;Ramaekers et al. 2010. Tolerance and cross-tolerance to neurocognitive effects of THC and alcohol in heavy cannabis users. Psychopharmacology 214: 391-401.</p>
<p class="smalltxt"><a id="32" name="32"></a><a href="http://www.norml.org/index.cfm?Group_ID=7459#b32">[32]</a>&nbsp;United Kingdom Department of Environment, Transport and the Regions, Road Safety Division&nbsp;<em>Cannabis and Driving: A Review of the Literature and Commentary.&nbsp;</em>Online document accessed November 24, 2007. &#8220;Overall, we conclude that the weight of the evidence indicates that &#8230; there is no evidence that consumption of cannabis alone increases the risk of culpability for traffic crash fatalities or injuries for which hospitalization occurs, and may reduce those risks.&#8221;</p>
<p class="smalltxt"><a href="http://www.norml.org/index.cfm?Group_ID=7459#b32">[33]</a>&nbsp;Gregory Chesher and Marie Longo. &#8220;Cannabis and Alcohol in Motor Vehicle Accidents,&#8221; In:&nbsp;<em>Cannabis and Cannabinoids: Pharmacology, Toxicology, and Therapeutic Potential</em>. (eds. Grotenhermen et al.) Haworth Press, 2002.</p>
<p class="smalltxt"><a id="34" name="34"></a><a href="http://www.norml.org/index.cfm?Group_ID=7459#b34">[34]</a>&nbsp;US Department of Transportation, National Highway Traffic Safety Administration. Marijuana and Actual Driving Performance: Final Report. op. cit.</p>
<p class="smalltxt"><a id="35" name="35"></a><a href="http://www.norml.org/index.cfm?Group_ID=7459#b35">[35]</a>&nbsp;Blows et al. 2004. Marijuana use and car crash injury.&nbsp;<em>Addiction</em>&nbsp;100: 605-611.</p>
<p class="smalltxt"><a id="36" name="36"></a><a href="http://www.norml.org/index.cfm?Group_ID=7459#b36">[36]</a>&nbsp;Movig et al. 2004. Psychoactive substance use and the risk of motor vehicle accidents.<em>Accident Analysis and Prevention</em>&nbsp;36: 631-636.</p>
<p class="smalltxt"><a id="37" name="37"></a><a href="http://www.norml.org/index.cfm?Group_ID=7459#b37">[37]</a>&nbsp;Drummer et al. 2004. The involvement of drugs in drivers killed in Australian road traffic crashes. Accident, Analysis and Prevention 36: 239-248. &#8220;Drivers with THC in their blood had a significantly higher likelihood of being culpable than drug-free drivers. For drivers with blood THC concentrations of 5 ng/ml or higher the odds ratio was greater and more statistically significant.&#8221;</p>
<p class="smalltxt"><a href="http://www.norml.org/index.cfm?Group_ID=7459#b37">[38]</a>&nbsp;Laumon et al. 2005. Cannabis intoxication and fatal road crashes in France: a population base case-control study. British Medical Journal 331: 1371-1377.</p>
<p class="smalltxt"><a href="http://www.norml.org/index.cfm?Group_ID=7459#b37">[39]</a>&nbsp;Sewell et al. 2009. The effect of cannabis compared with alcohol on driving. The American Journal on Addictions 18: 185-193. &#8220;Case-control studies are inconsistent, but suggest that while low concentrations of THC do not increase the rate of accidents, and may even decrease them serum concentrations of THC higher than 5 ng/mL are associated with an increased risk of accidents.&#8221;</p>
<p class="smalltxt"><a id="40" name="40"></a><a href="http://www.norml.org/index.cfm?Group_ID=7459#b40">[40]</a>&nbsp;Bedard et al. 2007. The impact of cannabis on driving.&nbsp;<em>Canadian Journal of Public Health</em>98: 6-11.</p>
<p class="smalltxt"><a id="41" name="41"></a><a href="http://www.norml.org/index.cfm?Group_ID=7459#b41">[41]</a>&nbsp;Laumon et al. 2005. Cannabis intoxication and fatal road crashes in France: a population base case-control study. op. cit.</p>
<p class="smalltxt"><a id="42" name="42"></a><a href="http://www.norml.org/index.cfm?Group_ID=7459#b42">[42]</a>&nbsp;Ramaekers. Commentary on Cannabis and Crash Risk: Concentration Effect Relation. In: Transportation Research Circular E-C096: Drugs and Traffic. 2006.</p>
<p class="smalltxt"><a href="http://www.norml.org/index.cfm?Group_ID=7459#b42">[43]</a>&nbsp;Grotenhermen et al. 2007. Developing per se limits for driving under cannabis. Addiction 102: 1910-1917.</p>
<p class="smalltxt"><a id="44" name="44"></a><a href="http://www.norml.org/index.cfm?Group_ID=7459#b44">[44]</a>&nbsp;Ramaekers et al. Dose related risk of motor vehicle crashes after cannabis use: an update. In: Drugs, Driving, and Traffic Safety (eds. Vester et al.) World Health Organization, 2009. &#8220;Individual drivers can vary widely in their sensitivity for THC induced impairment as evinced by the weak correlations between THC in serum and magnitude of performance impairment.&#8221;</p>
<p class="smalltxt"><a id="45" name="45"></a><a href="http://www.norml.org/index.cfm?Group_ID=7459#b45">[45]</a>&nbsp;US Department of Transportation, National Highway Traffic Safety Administration. Marijuana and Actual Driving Performance: Final Report. op. cit. &#8220;One of the program&#8217;s objectives was to determine whether it is possible to predict driving impairment by plasma concentrations of THC and/or its metabolite, THC-COOH, in single samples. The answer is very clear: it is not. Plasma of drivers showing substantial impairment in these studies contained both high and low THC concentrations; and drivers with high plasma concentrations showed substantial, but also no impairment, and even some improvement.&#8221;</p>
<p class="smalltxt"><a href="http://www.norml.org/index.cfm?Group_ID=7459#b45">[46]</a>&nbsp;Elliot et al. Marijuana DUI Workgroup: Recommendation to the Drug Policy Task Force and Colorado Commission on Criminal and Juvenile Justice. 2011. &#8220;Whereas BAC (Blood Alcohol Content) can be accurately measured and correlated with behavioral impairment, this may not be the case with cannabis &#8230; Alcohol is water soluble; cannabis is stored in the fat and is metabolized differently, making a direct correlation with behavior difficult to measure.&#8221;</p>
<p class="smalltxt"><a id="47" name="47"></a><a href="http://www.norml.org/index.cfm?Group_ID=7459#b47">[47]</a>&nbsp;Ramaekers et al. 2006. Cognition and motor control as a function of Delta-9-THC concentration in serum and oral fluid: Limits of impairment. op. cit.</p>
<p class="smalltxt"><a id="48" name="48"></a><a href="http://www.norml.org/index.cfm?Group_ID=7459#b48">[48]</a>&nbsp;Toennes et al. 2008. Comparison of cannabinoid pharmacokinetic properties in occasional and heavy users smoking a marijuana or placebo joint. op. cit.</p>
<p class="smalltxt"><a href="http://www.norml.org/index.cfm?Group_ID=7459#b48">[49]</a>&nbsp;Karschner et al. 2009. Do Delta- 9-tetrahydrocannabinol concentrations indicate recent use in chronic cannabis users? op. cit.</p>
<p class="smalltxt"><a id="50" name="50"></a><a href="http://www.norml.org/index.cfm?Group_ID=7459#b50">[50]</a>&nbsp;Toennes et al. 2008. Comparison of cannabinoid pharmacokinetic properties in occasional and heavy users smoking a marijuana or placebo joint. op. cit.</p>
<p class="smalltxt"><a id="51" name="51"></a><a href="http://www.norml.org/index.cfm?Group_ID=7459#b51">[51]</a>&nbsp;Wille et al. 2010. Conventional and alternative matrices for driving under the influence of cannabis. Bioanalysis 2: 791-806. &#8220;[I]n DUID cases, the delay between the accident and the final blood draw can be long and back-extrapolation is not an option due to the complex pharmacokinetic profile of THC.&#8221;</p>
<p class="smalltxt"><a id="52" name="52"></a><a href="http://www.norml.org/index.cfm?Group_ID=7459#b52">[52]</a>&nbsp;According to the 2011 White House Drug Control Strategy, Action Items: 1.5.A: Encourage States to Adopt Per Se Drug Impairment Laws: &#8220;Fifteen states have passed laws clarifying that the presence of any illegal drug in a driver&#8217;s body is per se evidence of impaired driving. ONDCP will work to expand the use of this standard to other states and explore other ways to increase the enforcement of existing DUID laws.&#8221; A state-by-state<a href="http://norml.org/index.cfm?Group_ID=6669">summary of DUI laws</a>&nbsp;is available from NORML.</p>
<p class="smalltxt"><a id="53" name="53"></a><a href="http://www.norml.org/index.cfm?Group_ID=7459#b53">[53]</a>&nbsp;Ramaekers et al. 2004. Dose related risk of motor vehicle crashes after cannabis use. Drug and Alcohol Dependence 73: 109-119. &#8220;Experimental studies have shown alcohol and THC combined can produce severe performance impairment even when given at low doses. The combined effect of alcohol and cannabis on performance and crash risk appeared additive in nature, i.e. the effects of alcohol and cannabis combined were always comparable to the sum of the effects of alcohol and THC when given alone.&#8221;</p>
<p class="smalltxt"><a id="54" name="54"></a><a href="http://www.norml.org/index.cfm?Group_ID=7459#b54">[54]</a>&nbsp;Ibid.</p>
<p class="smalltxt"><a id="55" name="55"></a><a href="http://www.norml.org/index.cfm?Group_ID=7459#b55">[55]</a>&nbsp;US Department of Justice, Bureau of Justice Statistics. op. cit.</p>
<p class="smalltxt"><a id="56" name="56"></a><a href="http://www.norml.org/index.cfm?Group_ID=7459#b56">[56]</a>&nbsp;US Department of Health and Human Services, Substance and Mental Health Services Association, Office of Applied Studies. 1998. op. cit.</p>
<p class="smalltxt"><a id="57" name="57"></a><a href="http://www.norml.org/index.cfm?Group_ID=7459#b57">[57]</a>&nbsp;Ibid.</p>
<p class="smalltxt"><a id="58" name="58"></a><a href="http://www.norml.org/index.cfm?Group_ID=7459#b58">[58]</a>&nbsp;Canadian Public Health Association. &#8220;The Pot and Driving Campaign.&#8221;</p>
<p class="smalltxt"><a id="59" name="59"></a><a href="http://www.norml.org/index.cfm?Group_ID=7459#b59">[59]</a>&nbsp;US Government Accountability Office. ONDCP Media Campaign: Contractor&#8217;s National Evaluation Did Not Find that the Youth Anti-Drug Media Campaign Was Effective in Reducing Youth Drug Use: Report to the Subcommittee on Transportation, Treasury, the Judiciary, Housing and Urban Development, and Related Agencies, Committee on Appropriations, U.S. Senate. August 25, 2006.</p>
<p class="smalltxt"><a id="60" name="60"></a><a href="http://www.norml.org/index.cfm?Group_ID=7459#b60">[60]</a>&nbsp;<a href="http://www.coloradodot.info/programs/alcohol-and-impaired-driving" target="_blank">http://www.coloradodot.info/programs/alcohol-and-impaired-driving</a></p>
<p class="smalltxt"><a id="61" name="61"></a><a href="http://www.norml.org/index.cfm?Group_ID=7459#b61">[61]</a>&nbsp;Papafotiou et al. 2005. An evaluation of the sensitivity of the Standardised Field Sobriety Tests (SFSTs) to detect impairment due to marijuana intoxication. Psychopharmacology 180: 107-114.</p>
<p class="smalltxt"><a id="62" name="62"></a><a href="http://www.norml.org/index.cfm?Group_ID=7459#b62">[62]</a>&nbsp;Looby et al. 2007. Roadside sobriety tests and attitudes toward a regulated cannabis market. Harm Reduction Journal. Online document accessed November 24, 2007.</p>
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